Paper Details

  1. Home
  2. Paper Details

Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock.

Author: CirioniOscar, D'AmatoGiuseppina, GhiselliRoberto, GiacomettiAndrea, KamyszWojciech, MocchegianiFederico, OrlandoFiorenza, RocchiMarco, SabaVittorio, ScaliseGiorgio, SilvestriCarmela, ŁukasiakJerzy

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pexiganan is a new antibiotic that is effective in treating septic shock in rats. When combined with betalactam antibiotics, pexiganan was even more effective.
Paper Details　
Original Abstract of the Article :
To investigate the efficacy of pexiganan, a 22-residue magainin analog, alone and combined with betalactmas antibiotics in three experimental rat models of Gram-negative septic shock. Adult male Wistar rats were given (i) an intraperitoneal injection of 1 mg Escherichia coli 0111:B4 LPS; (ii) 2x10(1...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.peptides.2004.09.012

データ提供：米国国立医学図書館（NLM）

Pexiganan: A New Weapon in the Desert of Septic Shock

Septic shock, a life-threatening condition caused by severe infection, is like a sandstorm that can engulf a fragile desert ecosystem. This study evaluated the effectiveness of pexiganan, a synthetic antimicrobial peptide, in treating experimental models of septic shock. The researchers found that pexiganan, alone or in combination with betalactam antibiotics, reduced mortality and bacterial growth in the blood and abdominal fluid. This is like finding a new weapon that can fight back against the desert storm.

Combating Septic Shock: A Multifaceted Approach

The study showed that pexiganan had a significant impact on reducing endotoxin and TNF-alpha levels, key components of the immune response in septic shock. This is like finding a new oasis that provides a source of fresh water and helps to cool down the desert heat. The combination of pexiganan and betalactam antibiotics proved to be the most effective treatment in reducing mortality and bacterial growth. It's like combining the strength of a camel with the speed of a cheetah to navigate the desert efficiently.

A Camel's Guide to Surviving the Desert Storm

Septic shock is a serious and complex condition requiring prompt medical attention. It's like being lost in a desert storm and needing to find shelter and resources quickly. This study highlights the potential of pexiganan as a promising new treatment option for septic shock, offering a ray of hope in the face of this deadly condition.

Dr. Camel's Conclusion

This study provides exciting insights into the potential of pexiganan as a novel antimicrobial agent for the treatment of septic shock. The drug's ability to reduce endotoxin and TNF-alpha levels, along with its synergistic effect with betalactam antibiotics, offers a promising strategy for combating this challenging condition. It's like discovering a new weapon that can help us conquer the desert storms of infection.

Date :
  1. Date Completed 2005-06-28
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

15629532

DOI: Digital Object Identifier

10.1016/j.peptides.2004.09.012

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.