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Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers.

Author: HantsbargerG, HuntR H, JamesC, KarimA, NicholsonP A, RainsfordK D, RischkeJ A, SmithM, StetskoP I

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Misoprostol did not interfere with the absorption of indomethacin but enhanced its steady-state maximum concentration.
Paper Details　
Original Abstract of the Article :
The effects of misoprostol (200 micrograms as a single dose or q.i.d. as a multiple dose) on the pharmacokinetics of indomethacin (100 mg single-dose administration or 50 mg t.i.d. multiple-dose administration) were studied in 16 healthy human volunteers under single-dose and steady-state conditions...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.1992.41

データ提供：米国国立医学図書館（NLM）

Misoprostol and Indomethacin: A Tale of Two Medications

In the realm of pharmaceuticals, understanding how medications interact is essential. This study investigates the effects of misoprostol, a prostaglandin analog, on the pharmacokinetics of indomethacin, a nonsteroidal anti-inflammatory drug (NSAID). The researchers conducted a randomized, double-blind, placebo-controlled study to examine the influence of misoprostol on indomethacin's absorption, distribution, metabolism, and elimination.

Misoprostol's Influence: Enhanced Indomethacin Levels

The study revealed that while misoprostol did not affect the overall absorption of indomethacin, it significantly increased its steady-state maximum concentration by 32%. This finding suggests that misoprostol might potentiate the effects of indomethacin, potentially leading to increased therapeutic efficacy or side effects.

Understanding Drug Interactions: A Crucial Step in Safe Medication Use

This research emphasizes the importance of being aware of potential drug interactions. In this case, the study reveals that misoprostol can significantly enhance the levels of indomethacin, highlighting the need for careful monitoring and dose adjustments when these two medications are used together.

Dr. Camel's Conclusion

This study reminds us that the desert of drug interactions can be full of unexpected twists and turns! Understanding how different medications interact is crucial for ensuring patient safety and maximizing therapeutic benefits. Remember, when navigating the landscape of medications, it's essential to be mindful of the potential interactions that can arise.

Date :
  1. Date Completed 1992-05-21
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

1563211

DOI: Digital Object Identifier

10.1038/clpt.1992.41

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Languages

English

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