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Cellular mechanisms of insulin resistance, lipodystrophy and atherosclerosis induced by HIV protease inhibitors.

Author: BashanN, Ben-RomanoR, EtzionS, RudichA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study explores the cellular mechanisms by which HIV protease inhibitors (HPIs) contribute to insulin resistance, dyslipidemia, lipodystrophy, and atherosclerosis. It discusses the roles of impaired glucose transport, defective insulin signaling, disrupted adipogenesis, and increased free radical production.
Paper Details　
Original Abstract of the Article :
Accumulating clinical evidence now links HIV protease inhibitors (HPIs) to the pathogenesis of insulin resistance, dyslipidaemia, lipodystrophy and atherosclerosis associated with highly active anti-retroviral therapy. Here we briefly describe the evidence for a distinct causative role for HPIs, and...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-201X.2004.01383.x

データ提供：米国国立医学図書館（NLM）

HIV Protease Inhibitors: A Double-Edged Sword

HIV protease inhibitors (HPIs) have revolutionized the treatment of HIV infection, but they can have significant side effects. This research delves into the cellular mechanisms underlying these side effects, focusing on insulin resistance, lipodystrophy, and atherosclerosis. Imagine a delicate balance within the body, like a fragile ecosystem within a desert. HPIs, like a powerful force in the desert, can disrupt this delicate balance, leading to unintended consequences. This research explores how HPIs impact cellular processes, shedding light on the potential mechanisms behind these side effects.

HPIs: Understanding the Unintended Consequences

This research unveils the complex interplay between HPIs and cellular function, revealing the potential mechanisms behind their side effects. It's like understanding the impact of a sudden storm in the desert, disrupting the delicate balance of life and causing unintended consequences. The findings provide valuable insights into the potential risks associated with HPIs and highlight the need for ongoing research to mitigate these challenges.

HIV Treatment: A Balancing Act

This research highlights the importance of considering the potential side effects of HPIs while managing HIV infection. It underscores the need for careful monitoring and personalized treatment plans to minimize risks and optimize patient well-being. This research reminds us that even the most powerful tools can have unintended consequences, and navigating complex health challenges requires a balanced and informed approach.

Dr.Camel's Conclusion

This research delves into the intricate world of HPIs and their impact on cellular processes, like exploring the hidden complexities of a desert oasis. It unveils the potential mechanisms behind their side effects, highlighting the importance of ongoing research to find solutions and navigate the challenges of managing HIV infection.

Date :
  1. Date Completed 2005-05-03
  2. Date Revised 2011-11-17
Further Info :

Pubmed ID

15654921

DOI: Digital Object Identifier

10.1111/j.1365-201X.2004.01383.x

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Languages

English

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