High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia.

Author: BartensteinPeter, BuchholzHans-Georg, GründerGerhard, HiemkeChristoph, HärtterSebastian, RöschFrank, SiessmeierThomas, StoeterPeter, VernalekenIngo

Paper Details 
Original Abstract of the Article :
The 'atypicality' of the antipsychotic drug, amisulpride, has been attributed to preferential extrastriatal binding. Previous investigations of striatal D2 receptor occupancy by amisulpride revealed conflicting results. The aim of this PET study was to measure the striatal occupancy by amisulpride a...See full text at original site
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引用元:
https://doi.org/10.1017/S1461145704004353

データ提供:米国国立医学図書館(NLM)

The Desert of Schizophrenia: Seeking Effective Treatments

The desert of schizophrenia is a challenging landscape, marked by complex symptoms and a need for effective treatments. This research explores the effectiveness of amisulpride, an atypical antipsychotic, in treating this condition.

The researchers, like desert explorers seeking a source of relief, investigate the striatal occupancy of D2-like dopamine receptors by amisulpride in patients with schizophrenia. They use PET imaging to measure the levels of amisulpride binding to these receptors in the brain, aiming to understand the relationship between drug concentrations and therapeutic effects.

The Oasis of Amisulpride: Understanding Its Effects

This research reveals that amisulpride can achieve high levels of striatal D2-like receptor occupancy in patients with schizophrenia. This finding suggests that amisulpride, even at lower doses, can effectively target the dopamine system, which is believed to play a role in the symptoms of schizophrenia. It’s like finding a hidden oasis with a rich source of water, capable of sustaining life even in the most arid environments.

Navigating the Desert of Schizophrenia: Finding Effective Therapies

This research highlights the potential of amisulpride as an effective treatment for schizophrenia. It’s a reminder that even in the vast and often challenging desert of mental illness, there are often oases of hope waiting to be discovered.

Dr. Camel's Conclusion

This research, like a journey through a desert of complex mental illness, provides valuable insights into the effectiveness of amisulpride in treating schizophrenia. It's a reminder that even in the most challenging landscapes, there are often hidden oases of knowledge waiting to be discovered.

Date :
  1. Date Completed 2005-02-24
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

15683553

DOI: Digital Object Identifier

10.1017/S1461145704004353

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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