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Continuous dopaminergic stimulation reduces risk of motor complications in parkinsonian primates.

Author: BibbianiFrancesco, ChaseThomas N, CostantiniLauren C, PatelRaj

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of continuous dopaminergic stimulation in MPTP-lesioned monkeys with Parkinson's disease. Continuous stimulation with apomorphine rods significantly improved motor function without inducing dyskinesias.
Paper Details　
Original Abstract of the Article :
Levodopa or short-acting dopamine (DA) agonist treatment of advanced parkinsonian patients exposes striatal DA receptors to non-physiologic intermittent stimulation that contributes to the development of dyskinesias and other motor complications. To determine whether continuous dopaminergic stimulat...See full text at original site
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引用元：
https://doi.org/10.1016/j.expneurol.2004.11.013

データ提供：米国国立医学図書館（NLM）

Continuous Dopaminergic Stimulation and Parkinson's Disease

This study explores the potential of continuous dopaminergic stimulation to reduce the risk of motor complications in Parkinson's disease. The researchers investigated the effects of continuous apomorphine delivery in MPTP-lesioned monkeys, a model of Parkinson's disease. They aimed to determine whether continuous stimulation of dopamine receptors could delay or prevent the development of motor complications associated with intermittent levodopa therapy.

Continuous Dopaminergic Stimulation: A New Approach to Parkinson's

This study, like a camel discovering a hidden oasis, reveals a promising new approach for managing Parkinson's disease. The researchers found that continuous dopaminergic stimulation, delivered via apomorphine-containing rods, significantly improved motor function in MPTP-lesioned monkeys and prevented the development of dyskinesias, a common motor complication associated with intermittent levodopa therapy.

Hope for Parkinson's Patients: A New Therapeutic Horizon

The study's findings suggest that continuous dopaminergic stimulation holds great promise as a new therapeutic strategy for managing Parkinson's disease. The research paves the way for the development of novel drug delivery systems that can provide sustained dopamine stimulation, potentially improving the quality of life for individuals with Parkinson's.

Dr. Camel's Conclusion

This study, like a desert bloom emerging from the sand, offers a glimmer of hope for individuals struggling with Parkinson's disease. The research highlights the potential of continuous dopaminergic stimulation to mitigate motor complications, suggesting a new path towards managing this debilitating condition.

Date :
  1. Date Completed 2005-04-14
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15698620

DOI: Digital Object Identifier

10.1016/j.expneurol.2004.11.013

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・Effects of apomorphine injection
SNS
PICO Info
in preparation
Languages

English

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