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Investigations of calsequestrin as a target for anthracyclines: comparison of functional effects of daunorubicin, daunorubicinol, and trifluoperazine.

Author: BroylesT Stephen, CharlierHenry A, CusackBarry J, LarsonCorianton L, MercerWendy K, MuhlesteinDawn J, OlsonDavid R, OlsonRichard D, ShadleSusan E, ThornockCarissa M

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the mechanism of anthracycline cardiotoxicity. Anthracyclines were found to bind to calsequestrin (CSQ) and inhibit SR calcium release, potentially contributing to anthracycline cardiotoxicity.
Paper Details　
Original Abstract of the Article :
Anthracycline therapy is associated with a life-threatening but poorly understood cardiotoxicity. Effects of treatment are consistent with drug-induced disruption of cardiac sarcoplasmic reticulum (SR) calcium homeostasis, including inhibition of calcium release by anthracyclines. This effect, which...See full text at original site
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引用元：
https://doi.org/10.1124/mol.104.005728

データ提供：米国国立医学図書館（NLM）

Calsequestrin as a Target for Anthracyclines: Investigating Cardiotoxicity

This research delves into the [mechanisms of anthracycline cardiotoxicity], exploring the potential role of [calsequestrin (CSQ)] in [cardiac toxicity] associated with [anthracycline therapy]. The study utilizes [protein fluorescence quenching studies] and [muscle preparations] to investigate the [interactions of anthracyclines with CSQ]. The findings suggest that [anthracyclines can impair SR calcium release and cardiac function through a mechanism involving disruption of CSQ function], highlighting the [importance of understanding these interactions] for [preventing and managing cardiotoxicity].

The Heart of the Matter: Understanding Anthracycline Cardiotoxicity

The study provides valuable insights into the [molecular mechanisms underlying anthracycline cardiotoxicity], emphasizing the [crucial role of CSQ] in [regulating calcium homeostasis] and [cardiac function]. The findings underscore the [importance of ongoing research] to develop [strategies for mitigating cardiotoxicity] and [improving patient outcomes] during anthracycline therapy.

Navigating the Desert of Cardiotoxicity: A Focus on Heart Health

Anthracycline therapy is a powerful tool in cancer treatment, but it can have serious side effects. This study sheds light on the [molecular mechanisms of cardiotoxicity], helping healthcare professionals [understand the risks] and [develop strategies] to [protect patients' heart health] during therapy.

Dr. Camel's Conclusion

Just as a camel traverses a desert, relying on its resilient heart to withstand the harsh conditions, individuals undergoing anthracycline therapy need careful monitoring and tailored approaches to protect their heart health. This study delves into the intricate world of cardiotoxicity, providing valuable insights for understanding and managing this challenging side effect of cancer treatment.
Date :
  1. Date Completed 2005-06-15
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

15705743

DOI: Digital Object Identifier

10.1124/mol.104.005728

Related Literature

Article Analysis
・Effects of trifluoperazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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