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A 1-year randomized study to evaluate the effects of a dose reduction in oral contraceptives on lipids and carbohydrate metabolism: 20 microg ethinyl estradiol combined with 100 microg levonorgestrel.

Author: DüsterbergBernd, EndrikatJan, GerlingerChristoph, GoldsteinHenri, JespersenJoergen, SchmidtWerner, SkoubySven O, WesselJens

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A one-third dose reduction in ethinyl estradiol (EE) and levonorgestrel (LNG) in oral contraceptives caused slightly lower, but insignificant, changes in lipid and carbohydrate variables compared to the reference treatment.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To evaluate the impact on lipid and carbohydrate variables of a combined one-third ethinyl estradiol (EE)/levonorgestrel (LNG) dose reduction in oral contraceptives. METHODS: In an open-label, randomized study, a dose-reduced oral contraceptive containing 20 microg EE and 100 microg LNG...See full text at original site
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引用元：
https://doi.org/10.1016/j.contraception.2004.08.017

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Hormonal Contraceptives: A Dose Reduction Study

The world of hormonal contraceptives is a vast desert, filled with diverse options and potential effects on the body. This study explores the impact of a dose reduction in oral contraceptives on lipid and carbohydrate metabolism. Researchers compared a new contraceptive containing lower doses of ethinyl estradiol (EE) and levonorgestrel (LNG) with a standard formulation. Their findings indicated that the dose-reduced contraceptive caused slightly lower changes in lipid and carbohydrate variables, although these differences were not statistically significant. This suggests that a reduced dose may offer a more balanced approach to managing the metabolic effects of hormonal contraceptives, paving the way for a more personalized approach to contraceptive care.

A More Balanced Approach: Dose Reduction in Hormonal Contraceptives

This study explores the potential of dose reduction in oral contraceptives, suggesting that a lower dose may provide a more balanced approach to managing metabolic effects. While the differences observed were not statistically significant, the findings indicate that a reduced dose may offer a more personalized and potentially safer approach for some individuals.

The Desert of Hormonal Contraceptives: Finding the Right Oasis

Choosing the right contraceptive can be a challenging journey, akin to navigating a vast desert. This study emphasizes the importance of individual needs and potential metabolic effects when choosing a contraceptive option. It highlights the potential of dose reduction as a way to tailor treatment, promoting a more personalized and potentially safer approach for some individuals.

Dr.Camel's Conclusion

The desert of hormonal contraceptives is vast and diverse, offering a range of options with varying effects on the body. This study underscores the importance of personalized approaches to contraceptive care, suggesting that dose reduction may provide a more balanced and potentially safer option for some individuals. It reminds us that in the vast landscape of hormonal contraceptives, finding the right oasis requires careful consideration of individual needs and potential metabolic effects.
Date :
  1. Date Completed 2005-12-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15707560

DOI: Digital Object Identifier

10.1016/j.contraception.2004.08.017

Related Literature

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・Effects of levonorgestrel
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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