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Artemisinin-based combination therapies for uncomplicated malaria.

Author: DavisTimothy M E, IlettKenneth F, KarunajeewaHarin A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Malaria parasite resistance to conventional antimalarial drugs has led to the development of short-course artemisinin-based combination therapies (ACTs) as first-line treatment for Plasmodium falciparum infections. ACTs combine artemisinin derivatives with partner drugs, offering a rapid schizontocidal effect and a longer-lasting action. While chloroquine and sulfadoxine-pyrimethamine may improve efficacy, their use as partners is limited to patients with some immunity to malaria. Other partner drugs like mefloquine, lumefantrine, and piperaquine are available, with varying efficacy, side effects, and costs. Dihydroartemisinin-piperaquine stands out as highly effective, well-tolerated, and relatively inexpensive. Future ACT development aims for potent, safe, easy-to-administer, and inexpensive options, potentially using trioxolanes and novel partner drugs.
Paper Details　
Original Abstract of the Article :
There has been a relentless increase in resistance of malaria parasites to conventional antimalarial drugs, including chloroquine, sulfadoxine-pyrimethamine and mefloquine. In response to this situation, short-course artemisinin-based combination therapies (ACTs) have been developed. The World Healt...See full text at original site
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引用元：
https://doi.org/10.5694/j.1326-5377.2005.tb06650.x

データ提供：米国国立医学図書館（NLM）

The Quest for a Powerful and Safe Malaria Cure

The field of malaria treatment is a vast and challenging desert, constantly shifting sands of drug resistance. This study delves into the complex world of artemisinin-based combination therapies (ACTs), a beacon of hope in this arid landscape. These therapies combine the rapid action of artemisinin derivatives with the staying power of partner drugs, aiming to outmaneuver the ever-evolving malaria parasite. The authors explore the effectiveness of various ACT combinations, highlighting the importance of finding a balance between efficacy, safety, and affordability. They emphasize that the search for new ACTs is a journey that continues, with potential future solutions lying in trioxolanes and novel partner drugs like pyronaridine and naphthoquine.

A Multifaceted Approach to Combatting Resistance

The study highlights the importance of a multifaceted approach to combatting drug resistance in malaria. This involves the careful selection of partner drugs, the development of new drug classes, and the careful monitoring of resistance patterns. This research underscores the need for a continuous and dynamic approach to the development of effective anti-malarial therapies.

The Importance of Global Collaboration

The use of ACTs is a testament to the importance of global collaboration in combating infectious diseases. The World Health Organization's endorsement of ACTs is a crucial step in coordinating efforts to reduce the burden of malaria worldwide. This study reminds us that the battle against infectious diseases requires a collective effort, with researchers, healthcare providers, and international organizations working hand in hand.

Dr.Camel's Conclusion

This study is a fascinating journey through the ever-changing landscape of malaria treatment. It highlights the importance of innovation, collaboration, and adaptability in developing effective therapies for this formidable disease. The quest for a powerful and safe malaria cure continues, and this research provides valuable insights into the path forward.

Date :
  1. Date Completed 2006-03-22
  2. Date Revised 2020-12-30
Further Info :

Pubmed ID

15720175

DOI: Digital Object Identifier

10.5694/j.1326-5377.2005.tb06650.x

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Languages

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