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Single-nucleotide polymorphisms in the 17beta-hydroxysteroid dehydrogenase genes might predict the risk of side-effects of estramustine phosphate sodium in prostate cancer patients.

Author: HaraKazuo, KadowakiTakashi, KameyamaShuji, KitamuraTadaichi, MutoSatoru, OzekiTakeshi, SuzukiMotofumi, TomitaKyoichi, YamadaYasuhiko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Estramustine phosphate sodium (EMP) frequently causes gastrointestinal discomfort, nausea, and edema in extremities. This study aims to analyze single nucleotide polymorphisms (SNPs) in the 17beta-hydroxysteroid dehydrogenase (HSD17B) genes, involved in EMP metabolism, to predict the risk of EMP side-effects in prostate cancer patients.
Paper Details　
Original Abstract of the Article :
Estramustine phosphate sodium (EMP) frequently causes side-effects such as gastrointestinal discomfort, nausea, and edema in extremities. We analyzed single nucleotide polymorphisms (SNP) in the 17beta-hydroxysteroid dehydrogenase (HSD17B) genes, which are involved in the metabolism of EMP, to predi...See full text at original site
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引用元：
https://doi.org/10.1111/j.1442-2042.2005.01004.x

データ提供：米国国立医学図書館（NLM）

Estramustine Phosphate Sodium: Predicting Side Effects Through Genetic Clues

The field of [oncology] is a complex and ever-evolving desert, with researchers constantly seeking to improve the efficacy and safety of cancer treatments. This research focuses on the potential of [single nucleotide polymorphisms (SNPs)] in [17beta-hydroxysteroid dehydrogenase (HSD17B) genes] to predict the risk of [side effects] associated with [estraustine phosphate sodium (EMP)] in [prostate cancer] patients. The study explores the potential for [genetic testing] to personalize [cancer treatment] and minimize the risk of adverse events.

Genetic Clues: Predicting Side Effects of Estramustine Phosphate Sodium

This study, like a desert explorer unearthing ancient secrets, reveals the potential of [genetic testing] to personalize [cancer treatment] and minimize the risk of [side effects]. The researchers' findings suggest that [SNPs] in [HSD17B genes] may play a role in determining the likelihood of experiencing [side effects] from [EMP] in [prostate cancer] patients.

Personalized Cancer Treatment: The Power of Genetics

This study, like a well-stocked oasis in a dry desert, provides valuable insights into the potential of [genetics] to personalize [cancer treatment]. The researchers' findings highlight the importance of considering [genetic factors] when choosing [cancer therapies], potentially improving treatment outcomes and reducing the risk of [side effects] for patients.

Dr.Camel's Conclusion

This research offers a promising new approach to [cancer treatment], emphasizing the potential of [genetics] to personalize therapy and minimize the risk of [side effects]. The study's findings underscore the need for ongoing research into the role of [genetic factors] in [cancer treatment], paving the way for more effective and personalized approaches to combating this complex disease. It's a reminder that even in the vast and often challenging desert of [cancer treatment], the quest for new solutions and personalized approaches continues to yield valuable discoveries.

Date :
  1. Date Completed 2005-07-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15733111

DOI: Digital Object Identifier

10.1111/j.1442-2042.2005.01004.x

Related Literature

Article Analysis
・Side Effects of estramustine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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