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Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum.

Author: ChangEugene B, HanauerStephen B, KlesKeri A, MuschMark W, TurnerJerrold R, VavrickaStephan R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Aminosalicylates are commonly used for mild-to-moderate ulcerative colitis, and pro-drug formulations like olsalazine have been associated with dose-dependent diarrhea in 17% of patients. This study investigates whether the azo linkages in these pro-drugs are responsible for increased secretion.
Paper Details　
Original Abstract of the Article :
The aminosalicylates remain foundation therapy for mild-to-moderate ulcerative colitis. Pro-drug 5-aminosalicylic acid (5-ASA; mesalamine) formulations have been developed to prevent 5-ASA from the proximal absorption and release of mesalamine, to decrease inflammation, and to improve colonic absorp...See full text at original site
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引用元：
https://doi.org/10.1097/01.mib.0000160806.53858.55

データ提供：米国国立医学図書館（NLM）

Aminosalicylates in Ulcerative Colitis: Examining the Secret Oasis

Ulcerative colitis, a chronic inflammatory bowel disease, can be a challenging condition, much like navigating a scorching desert. Aminosalicylates, a class of medications used to treat mild-to-moderate ulcerative colitis, have been a key tool in managing this disease. This research delves into the prosecretory effects of different aminosalicylate formulations, investigating their potential impact on intestinal secretion.

The authors examine the effects of balsalazide, sulfasalazine, olsalazine, and mesalamine on rabbit distal ileum. They find that compounds containing azo linkages, like olsalazine, can induce ileal secretion, potentially leading to dose-dependent diarrhea. This finding, much like discovering a hidden oasis with potentially dangerous currents, highlights the importance of understanding the nuances of these medications.

A Hidden Oasis with Potential Hazards: Navigating Aminosalicylates

This research reveals that certain aminosalicylate formulations, particularly those containing azo linkages, can induce intestinal secretion, potentially leading to unwanted side effects. This discovery, much like uncovering a hidden oasis with potentially dangerous currents, underscores the importance of careful medication selection and monitoring for patients with ulcerative colitis.

A Cautious Approach to Aminosalicylate Therapy

This research highlights the importance of understanding the prosecretory effects of different aminosalicylate formulations. It emphasizes the need for careful monitoring and adjustment of medications, minimizing the risk of unwanted side effects. This cautious approach, much like a seasoned traveler navigating a treacherous desert landscape, ensures the best possible outcome for patients with ulcerative colitis.

Dr. Camel's Conclusion

This research explores the prosecretory effects of different aminosalicylate formulations, highlighting the importance of careful medication selection and monitoring for patients with ulcerative colitis. The authors emphasize the need to consider the potential risks and benefits of these medications, ensuring optimal treatment outcomes.

Date :
  1. Date Completed 2005-06-07
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

15735431

DOI: Digital Object Identifier

10.1097/01.mib.0000160806.53858.55

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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