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Psychiatric side effects of pegylated interferon alfa-2b as compared to conventional interferon alfa-2b in patients with chronic hepatitis C.

Author: CsefHerbert, KrausMichael-R, ScheurlenMichael, SchäferArne

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Peginterferon alfa-2b and conventional interferon alfa-2b were found to be equally effective in treating chronic hepatitis C. However, peginterferon alfa-2b was associated with a higher frequency of depression and anger/hostility symptoms.
Paper Details　
Original Abstract of the Article :
AIM: To assess systematically the spectrum and extent of depressive symptoms comparing patient groups receiving peginterferon or conventional interferon. METHODS: Ninety-eight patients with chronic hepatitis C and interferon-based therapy (+ribavirin) were consecutively enrolled in a longitudinal s...See full text at original site
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引用元：
https://doi.org/10.3748/wjg.v11.i12.1769

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Hepatitis C Treatment: Psychiatric Side Effects of Interferon

Hepatitis C, a viral infection that can cause liver damage, is a challenging journey through the desert of illness. This research investigates the psychiatric side effects of two types of interferon therapy: pegylated interferon alfa-2b and conventional interferon alfa-2b. The study compared the incidence of depressive symptoms in patients receiving either type of interferon, both in combination with ribavirin, a medication used to treat hepatitis C.

The Desert of Depression: Interferon Side Effects

The study found that both types of interferon therapy were associated with similar levels of depressive symptoms. However, the study also noted that pegylated interferon therapy was associated with a higher frequency of clinically relevant depression, highlighting the need for careful monitoring and management of psychiatric side effects during interferon treatment.

A Desert Oasis of Support: Managing Psychiatric Side Effects

This research emphasizes the importance of recognizing and addressing psychiatric side effects during interferon therapy. Patients receiving interferon therapy should be closely monitored for signs of depression and other mental health issues. Early intervention and appropriate support can help individuals manage these side effects and improve their overall well-being. By addressing these potential challenges, we can help patients navigate the desert of hepatitis C treatment with greater strength and resilience.

Dr. Camel's Conclusion

This study highlights the importance of considering the potential psychiatric side effects of interferon therapy, particularly pegylated interferon. By recognizing these potential challenges and providing appropriate support, we can help individuals navigate the desert of hepatitis C treatment with greater ease and achieve optimal outcomes.

Date :
  1. Date Completed 2005-05-11
  2. Date Revised 2019-04-30
Further Info :

Pubmed ID

15793861

DOI: Digital Object Identifier

10.3748/wjg.v11.i12.1769

SNS
PICO Info
in preparation
Languages

English

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