Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo.

Author: ChangIh Seoup, ChungJin Ho, KimMi Sun, LeeByeong Gon, LeeJin Young, LeeSerah, SonEui Dong

Paper Details 
Original Abstract of the Article :
To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular matrix proteins in aged human skin, 17beta-estradiol (0.01%) and its vehicle (70% propylene glycol, 30% ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under o...See full text at original site
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引用元:
https://doi.org/10.1111/j.0022-202X.2005.23736.x

データ提供:米国国立医学図書館(NLM)

Topical 17beta-Estradiol: A Fountain of Youth for Aging Skin?

As we journey through life, our skin tells the tale of our adventures. This study investigates the potential of topically applied 17beta-estradiol to rejuvenate aging skin. Researchers applied 17beta-estradiol to the skin of older individuals and observed its effects on the production of extracellular matrix proteins, which are essential for skin structure and elasticity. They discovered that 17beta-estradiol significantly increased the production of type 1 procollagen and tropoelastin, leading to improvements in skin thickness and appearance. It's like a desert spring, bringing life and vibrancy back to aging skin.

The Potential of Estrogen for Skin Rejuvenation

The study's findings suggest that topical 17beta-estradiol could be a valuable tool for addressing the signs of aging skin. By stimulating the production of essential extracellular matrix proteins, 17beta-estradiol may help to restore skin thickness, reduce wrinkles, and improve overall skin texture. This research holds promise for developing effective skincare products that target the underlying mechanisms of skin aging.

Estrogen and Skin Health: A Journey Through Time

While further research is needed to fully understand the long-term effects of topical 17beta-estradiol on skin health, this study provides a glimpse into the potential of estrogen to counteract the aging process. It's like a time traveler, rewinding the clock on aging skin, offering a glimmer of hope for maintaining youthful vitality.

Dr.Camel's Conclusion

This study suggests that topical 17beta-estradiol could be a valuable tool for rejuvenating aging skin by stimulating the production of key extracellular matrix proteins. While further research is needed, this finding offers a glimmer of hope for slowing down the sands of time and preserving youthful skin.

Date :
  1. Date Completed 2005-08-02
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

15955089

DOI: Digital Object Identifier

10.1111/j.0022-202X.2005.23736.x

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PICO Info
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Languages

English

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