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Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients.

Author: FraserAbigail, Gafter-GviliAnat, LeiboviciLeonard, PaulMical

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Antibiotic prophylaxis for neutropenic patients undergoing cytotoxic therapy reduces mortality, with fluoroquinolones demonstrating the most substantial reduction. Antibiotic prophylaxis, preferably with a fluoroquinolone, should be considered for neutropenic patients.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Bacterial infections are a major cause of illness and death in patients who are neutropenic after chemotherapy treatment for cancer. Trials have shown the efficacy of antibiotic prophylaxis in decreasing the incidence of bacterial infections but not in reducing mortality rates. PURPOSE:...See full text at original site
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引用元：
https://doi.org/10.7326/0003-4819-142-12_part_1-200506210-00008

データ提供：米国国立医学図書館（NLM）

Antibiotic Prophylaxis for Neutropenic Patients: A Life-Saving Strategy

The study explores the crucial role of antibiotic prophylaxis in reducing mortality in neutropenic patients undergoing chemotherapy. The authors conducted a meta-analysis of numerous randomized controlled trials to evaluate the effectiveness of antibiotic prophylaxis in preventing bacterial infections and improving survival rates.

Fighting Infection: A Proactive Approach

The meta-analysis revealed a significant decrease in the risk of death in neutropenic patients who received antibiotic prophylaxis compared to those who received placebo or no treatment. The authors further found that fluoroquinolone prophylaxis was particularly effective in reducing the risk of mortality, as well as infection-related complications.

Protecting Against Infections: A Critical Step

This study strongly supports the use of antibiotic prophylaxis for neutropenic patients undergoing chemotherapy. It emphasizes the crucial role of fluoroquinolones in reducing mortality and infection-related complications. The findings highlight the importance of proactively managing infection risk in vulnerable patients to improve survival outcomes.

Dr.Camel's Conclusion

This meta-analysis provides compelling evidence that antibiotic prophylaxis is a life-saving strategy for neutropenic patients undergoing chemotherapy. The findings underscore the importance of fluoroquinolone prophylaxis in reducing mortality and infection-related complications. This research serves as a reminder that proactive infection management is crucial for improving survival rates in this vulnerable population.

Date :
  1. Date Completed 2005-06-27
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

15968013

DOI: Digital Object Identifier

10.7326/0003-4819-142-12_part_1-200506210-00008

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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