A critical review of anagrelide therapy in essential thrombocythemia and related disorders.

Author: DingliDavid, TefferiAyalew

Paper Details 
Original Abstract of the Article :
Thrombocytosis is a common clinical problem and it represents either a primary myeloid disorder (a clonal process) or a reactive phenomenon. While reactive thrombocytosis is often inconsequential, clonal thrombocytosis may require cytoreductive therapy to prevent thrombohemorrhagic complications. In...See full text at original site
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引用元:
https://doi.org/10.1080/10428190400029817

データ提供:米国国立医学図書館(NLM)

Anagrelide in Thrombocytosis: A Critical Appraisal

Thrombocytosis, an abnormal increase in platelet count, can be a sign of underlying health issues. This study critically reviews the use of anagrelide, a medication used to lower platelet levels, in the management of essential thrombocythemia (ET) and related disorders. The researchers analyze the available evidence on anagrelide's efficacy and safety, considering its potential benefits and risks.

Anagrelide: A Controversial Treatment for Thrombocytosis

The study raises concerns about the widespread use of anagrelide in ET and PV, highlighting the lack of conclusive evidence supporting its clinical benefit. The researchers emphasize the need for caution in prescribing anagrelide, considering its potential for serious side effects.

A Need for Further Research and Evidence-based Treatment

This study underscores the importance of evidence-based medicine in guiding treatment decisions. The authors emphasize the need for rigorous research to establish the true efficacy and safety of anagrelide in managing thrombocytosis, ensuring that patients receive the most appropriate and effective treatment.

Dr. Camel's Conclusion

Imagine a desert oasis, offering a tempting respite from the harsh environment. Anagrelide, like an oasis, can offer relief from the challenges of thrombocytosis, but it's crucial to remember that not all oases are created equal. This study cautions us to carefully consider the potential benefits and risks of anagrelide, seeking a treatment strategy that is both effective and safe for each individual patient. It's a reminder that, in the vast desert of medical options, careful navigation is crucial to ensure a healthy and fulfilling journey.

Date :
  1. Date Completed 2005-09-15
  2. Date Revised 2019-01-16
Further Info :

Pubmed ID

16019501

DOI: Digital Object Identifier

10.1080/10428190400029817

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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