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Different patterns of relapse associated with three intensive treatment regimens for pediatric E-rosette positive T-cell leukemia: a Pediatric Oncology Group study.

Author: BorowitzM J, CristW M, FallettaJ M, ForemanE, PattersonR, PullenD J, ShusterJ J, ViettiT J, WharamM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A study of 193 children with T-cell acute lymphocytic leukemia (T-ALL) found that different treatment regimens had varying effects on the location of relapse. The study found that: - Intensified intrathecal chemotherapy (treatment in the spinal fluid) and cranial radiation significantly reduced the rate of central nervous system (CNS) relapse compared to less intensive intrathecal therapy without radiation. - A more complex multi-agent chemotherapy regimen was more effective in preventing testicular leukemia compared to a simpler regimen. - The study concluded that the effectiveness of treatments for specific areas of relapse (sanctuary sites) is dependent on the specific therapy used. - While all treatment groups had similar complete remission and 3-year event-free survival rates (around 90% and 40% respectively), these differences in relapse patterns highlight the importance of tailoring treatment plans to specific subtypes of cancer.
Paper Details　
Original Abstract of the Article :
One hundred and ninety-three children with T-cell acute lymphocytic leukemia (T-ALL) whose leukemia cells were E-rosette positive were treated on a Pediatric Oncology Group study (1979-1986) designed specifically for patients with T-ALL. The results of modified LSA2L2 therapy with or without intensi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1602793

データ提供：米国国立医学図書館（NLM）

Intensive Treatment Regimens for Pediatric E-Rosette Positive T-Cell Leukemia: A Comparative Journey

Pediatric E-rosette positive T-cell leukemia, a type of blood cancer, is like a desert mirage, initially appearing hopeful but potentially leading to relapses. This study, like a team of skilled oncologists, compares the effectiveness of three intensive treatment regimens for this condition. The researchers, armed with their knowledge of pediatric oncology and treatment protocols, meticulously analyzed data from a Pediatric Oncology Group study to determine the best approach for treating this challenging cancer. Their findings reveal that different treatment regimens can lead to distinct patterns of relapse, underscoring the importance of personalized and tailored therapies.

Treatment Regimens: A Comparative Oasis in the Desert of Leukemia

This research, like a camel evaluating different watering holes in a vast desert, compares the efficacy of three intensive treatment regimens for pediatric E-rosette positive T-cell leukemia. The researchers found that each regimen yielded different patterns of relapse, highlighting the importance of customizing treatment based on individual patient needs.

Navigating the Complex Landscape of Cancer Treatment

This study, like a skilled guide leading a caravan through a complex and ever-changing desert, underscores the importance of personalized and tailored therapies in the fight against cancer. The researchers found that different treatment regimens can lead to distinct patterns of relapse, emphasizing the need for individualized approaches to optimize treatment outcomes.

Dr. Camel's Conclusion

This research highlights the importance of personalized and tailored therapies in treating pediatric E-rosette positive T-cell leukemia. Each treatment regimen, like a different oasis in a vast desert, offers unique advantages and disadvantages. Understanding these differences allows for more effective and individualized treatment plans, potentially improving outcomes and minimizing relapse rates.

Date :
  1. Date Completed 1992-07-16
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

1602793

DOI: Digital Object Identifier

1602793

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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