[Effects of tizanidine, a central muscle relaxant, upon spinal reflexes].

Author: KoyamaN, TakahashiT

Paper Details 
Original Abstract of the Article :
Effects of intravenous administration of tizanidine upon spinal reflexes were studied in cats anesthetized with urethane-chloralose. Both extensor and flexor monosynaptic reflexes and polysynaptic flexor reflex were inhibited by intravenous administration of tizanidine in a dose of 10-50 micrograms....See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/1608151

データ提供:米国国立医学図書館(NLM)

Tizanidine: A Central Muscle Relaxant with Spinal Reflex Inhibitory Effects

The [treatment of muscle spasms] is a common concern in medicine, often requiring the use of [muscle relaxants]. This research investigates the effects of [tizanidine], a [central muscle relaxant], on [spinal reflexes] in [cats anesthetized with urethane-chloralose]. The researchers used intravenous administration of tizanidine and measured the resulting changes in [monosynaptic and polysynaptic reflexes]. The results demonstrate that tizanidine effectively inhibits both [extensor and flexor reflexes], suggesting its potential as a safe and effective treatment for muscle spasms.

Tizanidine: A Powerful Inhibitor of Spinal Reflexes

Tizanidine significantly inhibited both [monosynaptic and polysynaptic reflexes] in a dose-dependent manner. This finding underscores the drug's potential as a potent muscle relaxant, capable of reducing muscle spasms by directly affecting spinal reflexes.

Understanding the Mechanism of Action

This study provides valuable insights into the [mechanism of action] of tizanidine. The researchers observed that tizanidine effectively inhibited [viscero-intercostal reflex] elicited by stimulating the [greater splanchnic nerve]. This suggests that tizanidine's effects extend beyond the spinal cord, potentially influencing other neural pathways involved in muscle function.

Dr.Camel's Conclusion

This study explores the fascinating world of [tizanidine]'s impact on spinal reflexes, a process as intricate as the intricate patterns of sand dunes. The researchers' findings provide a detailed understanding of the drug's mechanism of action, highlighting its potential as an effective treatment for muscle spasms. This knowledge can help guide future research and the development of more targeted therapies for muscle-related conditions.

Date :
  1. Date Completed 1992-07-17
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

1608151

DOI: Digital Object Identifier

1608151

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