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Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis.
Author: BernardD, DelattreC, DonovanM, MéhulB, SchmidtR, Thomas-CollignonA
Original Abstract of the Article :
Proteases play a pivotal role in epidermal differentiation and desquamation. Separation of a total protein extract from human reconstructed epidermis by two-dimensional gel electrophoresis and subsequent peptide analysis of a specific protein spot identified a new protein exhibiting similarities wit...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1111/j.0022-202X.2005.23816.x
データ提供:米国国立医学図書館(NLM)
Identification and Characterization of SASPase: A Novel Aspartic Protease
The human body is a complex ecosystem, with a diverse cast of molecules playing crucial roles in maintaining its intricate balance. This research delves into the fascinating world of proteases, enzymes that break down proteins, focusing on a newly identified protease specifically expressed in the epidermis. The authors identify and characterize a novel aspartic protease, named SASPase, highlighting its unique properties and potential implications for skin health.
The authors demonstrate that SASPase is specifically expressed in the epidermis and plays a role in epidermal differentiation and desquamation. They also explore the potential therapeutic implications of inhibiting SASPase activity, suggesting that inhibitors of this protease could have potential applications in treating skin conditions.
SASPase: A New Player in Skin Biology
This research introduces SASPase as a novel protease involved in skin biology. The study provides valuable insights into the role of this protease in epidermal differentiation and desquamation, opening new avenues for understanding and potentially treating skin disorders.
The Potential of SASPase Inhibition
The authors suggest that inhibiting SASPase activity could have therapeutic implications for various skin conditions. Further research is needed to explore the potential of SASPase inhibitors as a new treatment modality for skin diseases.
Dr.Camel's Conclusion
The desert of skin biology is vast and complex, but this research sheds light on a new player in this intricate ecosystem. The identification and characterization of SASPase provides valuable insights into the mechanisms of skin health and opens new avenues for exploring potential therapeutic targets for treating skin disorders.
Date :
- Date Completed 2005-09-13
- Date Revised 2013-11-21
Further Info :
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