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Subjective and behavioral responses to intravenous fentanyl in healthy volunteers.

Author: LichtorJ L, ZacnyJ P, ZaragozaJ G, de WitH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Intravenous fentanyl produced dose-related increases in ratings of 'high' and 'sedated' in healthy volunteers, and some subjects reported liking the effects, indicating a potential risk for abuse.
Paper Details　
Original Abstract of the Article :
Fentanyl is a mu opiate agonist which is occasionally abused by medical personnel who have ready access to the drug. We examined in healthy volunteers (N = 13) the subjective and psychomotor-impairing effects of intravenous fentanyl (0-100 micrograms/70 kg). A randomized, placebo-controlled, crossov...See full text at original site
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引用元：
https://doi.org/10.1007/BF02245155

データ提供：米国国立医学図書館（NLM）

The Subjective and Behavioral Effects of Fentanyl: Understanding the Potential for Abuse

Fentanyl, a powerful opioid, is widely used in medicine but also carries a potential for abuse. This study investigates the subjective and behavioral effects of intravenous fentanyl in healthy volunteers. The researchers found that fentanyl produced dose-related increases in ratings of 'high' and 'sedated' but also tended to produce dysphoria and somatic symptomatology. While most subjects reported liking the effects of fentanyl for a brief period, they varied widely in their liking ratings over time. These findings highlight the potential for fentanyl to be abused, particularly among those with ready access to the drug, such as medical personnel. The study underscores the importance of awareness and education about the potential for fentanyl abuse.

The Desert of Opioids: Understanding the Complexities of Fentanyl

This study takes us into the vast and complex desert of opioids, exploring the unique effects of fentanyl. The findings highlight the potential for both pleasurable and negative effects, emphasizing the need for careful consideration of its use and potential for abuse. This research serves as a reminder that the use of opioids requires vigilance, awareness, and a commitment to preventing misuse.

Navigating the Risks of Fentanyl: A Call for Awareness and Education

This study underscores the importance of education and awareness regarding the potential for opioid abuse. The findings highlight the subjective and behavioral effects of fentanyl, emphasizing the need for caution and vigilance in its use. It's crucial for medical professionals and the general public to be informed about the risks associated with opioids and to take steps to prevent misuse.

Dr.Camel's Conclusion

This research is like a warning sign in the desert of opioids, reminding us to tread carefully and to be aware of the potential dangers. It's a reminder that even powerful medicines can be misused, and we must approach their use with wisdom and caution.

Date :
  1. Date Completed 1992-07-30
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

1615132

DOI: Digital Object Identifier

10.1007/BF02245155

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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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