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Inhibition of human and rabbit liver steroid and xenobiotic UDP-glucuronosyltransferases by tertiary amine drugs--implications for adverse drug reactions.
Author: CoughtrieM W, MakL Y, SharpS, SmithD J
Original Abstract of the Article :
1. To investigate the hypothesis that disruption of glucuronidation of endogenous compounds by drugs represents a potential mechanism for pathogenesis of adverse drug reactions, the effects of a range of tertiary amine and amide drugs (many with effects on sex hormone function) on steroid hormone an...See full text at original site
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引用元:
https://doi.org/10.3109/00498259209053098
データ提供:米国国立医学図書館(NLM)
Tertiary Amine Drugs: A Cautionary Tale in the Desert of Drug Metabolism
The world of drug metabolism is a vast and complex desert, where the body's intricate processes transform medications into usable forms. This research, like a careful explorer mapping out the terrain of drug metabolism, investigates the effects of tertiary amine drugs on the liver's ability to process both steroid hormones and foreign compounds. The study reveals that certain tertiary amine drugs can significantly disrupt this essential metabolic process, potentially leading to unintended consequences.
Tertiary Amine Drugs: A Potential for Drug Interactions
The study's findings are like discovering a hidden sandstorm in the desert of drug metabolism, revealing that tertiary amine drugs can interfere with the liver's ability to process both steroid hormones and xenobiotics (foreign compounds). This interference, like a disruption in the flow of a desert oasis, can potentially lead to drug interactions and adverse side effects. The research highlights the importance of understanding the potential interactions between drugs and the liver's metabolic pathways, emphasizing the need for careful medication management to minimize risks.
Navigating the Desert of Drug Metabolism with Caution
This research serves as a cautionary tale, reminding us that the desert of drug metabolism is not always a predictable or benign landscape. Tertiary amine drugs, like a hidden current in a desert river, can alter the course of drug metabolism, potentially leading to unintended consequences. This research underscores the importance of consulting with healthcare providers to understand potential drug interactions and minimize risks, allowing us to safely navigate the complex terrain of drug metabolism.
Dr.Camel's Conclusion
This study reminds us that even in the seemingly familiar desert of drug metabolism, there are hidden dangers waiting to be revealed. Tertiary amine drugs, like a mirage shimmering on the horizon, can appear harmless but can disrupt the body's intricate metabolic processes. This research underscores the importance of careful medication management, allowing us to navigate the desert of drug metabolism with caution and expertise.
Date :
- Date Completed 1992-07-29
- Date Revised 2019-09-07
Further Info :
Related Literature
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