Stress reduces the neuroprotective effect of exercise in a rat model for Parkinson's disease.

Author: HowellsFleur M, KellawayLauriston A, MabandlaMusa V, RussellVivienne A

Paper Details 
Original Abstract of the Article :
Parkinson's disease (PD) is a progressive neurodegenerative disease of nigrostriatal dopamine (DA) neurons that project from the substantia nigra pars compacta (SNc) to the striatum. To further understand PD, researchers have developed standardized animal models of PD. In this study, Long Evans (LE)...See full text at original site
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引用元:
https://doi.org/10.1016/j.bbr.2005.06.044

データ提供:米国国立医学図書館(NLM)

Stress and Exercise: Balancing the Scales in Parkinson's Disease

This study examines the neuroprotective effects of exercise in a rat model of Parkinson's disease (PD), a neurodegenerative disorder characterized by the loss of dopamine-producing neurons. The study explores the impact of stress on the neuroprotective benefits of exercise.

Stress and Neuroprotection: A Complex Interaction

The study reveals that stress can negate the neuroprotective effects of exercise in PD. Rats that were subjected to stress, even while engaging in voluntary exercise, showed similar levels of neuronal damage to those that did not exercise. This finding highlights the potential detrimental effects of stress on brain health in PD.

Managing Stress: A Key to Neuroprotection

This study underscores the importance of managing stress in patients with PD. Maintaining a healthy lifestyle, including regular exercise and stress-reduction techniques, may play a crucial role in protecting brain health and slowing disease progression.

Dr.Camel's Conclusion

Just as a desert traveler must navigate the harsh conditions of the environment, individuals with PD face challenges in managing their condition. This study demonstrates the delicate balance between stress and neuroprotection in PD. It reminds us that while exercise can be beneficial, managing stress is equally important for preserving brain health.

Date :
  1. Date Completed 2006-02-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16159673

DOI: Digital Object Identifier

10.1016/j.bbr.2005.06.044

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PICO Info
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Languages

English

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