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Safety and efficacy of irinotecan plus high-dose leucovorin and intravenous bolus 5-fluorouracil for metastatic colorectal cancer: pooled analysis of two consecutive southern Italy cooperative oncology group trials.

Author: BuzziFranco, ComellaPasquale, De CataldisGiuseppe, De LuciaLuigi, FarrisAntonio, FilippelliGianfranco, LeoSilvana, LorussoVito, MaiorinoLuigi, MancarellaSergio, MassiddaBruno, NataleDonato, PalmeriSergio, RoselliMario, TafutoSalvatore

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that patients with no weight loss and/or preserved performance status (PS) and with a limited disease extent appeared to obtain the greatest benefit from a biweekly regimen of irinotecan 200 mg/m2 on day 1 and levo-leucovorin (LV) 250 mg/m2 plus 5-fluorouracil (5-FU) 850 mg/m2 via intravenous bolus on day 2.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A biweekly regimen of irinotecan 200 mg/m2 on day 1 and levo-leucovorin (LV) 250 mg/m2 plus 5-fluorouracil (5-FU) 850 mg/m2 via intravenous bolus on day 2 was assessed in 2 consecutive randomized trials in metastatic colorectal cancer (CRC). PATIENTS AND METHODS: Individual data of 254 ...See full text at original site
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引用元：
https://doi.org/10.3816/ccc.2005.n.032

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2005-12-07
  2. Date Revised 2019-11-09
Further Info :

Pubmed ID

16197624

DOI: Digital Object Identifier

10.3816/ccc.2005.n.032

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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