Paper Details

  1. Home
  2. Paper Details

An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit hearts.

Author: BelardinelliLuiz, ShryockJohn C, SongYejia, WuLin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The proarrhythmic activities of drugs with very low to moderate risk of causing torsades de pointes were investigated in the presence of sea anemone toxin (ATX-II), an enhancer of the late sodium current. ATX-II potentiated the effects of QT-prolonging drugs to increase MAPD(90) and unmasked the proarrhythmic activities of these drugs at clinically relevant drug concentrations.
Paper Details　
Original Abstract of the Article :
Assessment of the proarrhythmic risk associated with drugs that prolong the QT interval is difficult. We hypothesized that the proarrhythmic activities of drugs with very low to moderate risk of causing torsades de pointes would be well differentiated when the late sodium current (I(NaL)) was greate...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1124/jpet.105.094862

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2006-04-04
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

16234410

DOI: Digital Object Identifier

10.1124/jpet.105.094862

Related Literature

Article Analysis
・Side Effects of ranolazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.