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Evaluation of a 1-year levonorgestrel-releasing contraceptive implant: side effects, release rates, and biodegradability.

Author: CookC E, DarneyP D, KlaisleC M, MonroeS E, PhillipsN R, SchindlerA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A 4.0-cm biodegradable, subdermal contraceptive implant containing levonorgestrel effectively suppressed ovulation in 80% of cycles over 1 year of use. The implant was well tolerated with minor side effects typical of progestin-only contraception.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine the release rates, effects on ovulation, and side effects of two lengths of a biodegradable, subdermal contraceptive implant containing levonorgestrel in a caprolactone capsule. DESIGN: Phase II randomized clinical trial. SETTING: Public family planning clinic at an urban g...See full text at original site
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引用元：
https://doi.org/10.1016/s0015-0282(16)55150-4

データ提供：米国国立医学図書館（NLM）

Levonorgestrel-Releasing Implant: A New Sandcastle in the Desert of Contraception

The world of contraception, like a vast desert landscape, is constantly evolving, with new technologies and approaches emerging to meet the diverse needs of individuals. This study, like a meticulous desert architect, examines the efficacy and safety of a novel biodegradable, subdermal levonorgestrel-releasing contraceptive implant. The authors, armed with scientific knowledge and careful observation, explore the release rates, effects on ovulation, and potential side effects of this implant. Their findings, like a carefully constructed sandcastle on the desert shore, provide valuable insights into the potential of this new contraceptive option.

Levonorgestrel-Releasing Implant: A Promising New Contraceptive Option

This study demonstrates that the 4.0 cm levonorgestrel-releasing implant effectively suppresses ovulation and provides adequate levonorgestrel levels for contraception over a 12-month period. The implant's ease of insertion and removal, along with its rapid biodegradability, make it a promising new contraceptive option for individuals seeking long-term, reversible contraception.

Levonorgestrel-Releasing Implant: A New Tool in the Contraceptive Toolkit

This study, like a desert traveler discovering a hidden spring, unveils a potentially valuable addition to the contraceptive toolkit. The levonorgestrel-releasing implant's efficacy, ease of use, and biodegradability make it a promising option for individuals seeking a long-term, reversible method of contraception. As with all contraceptive options, careful consideration of potential side effects and individualized needs is essential.

Dr.Camel's Conclusion

This study, like a shimmering mirage in the desert, offers a glimpse into the potential of a new contraceptive option. The levonorgestrel-releasing implant, with its long-term efficacy and ease of use, could reshape the landscape of contraception, offering a promising alternative for individuals seeking a reliable and reversible method of family planning.

Date :
  1. Date Completed 1992-08-11
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

1623994

DOI: Digital Object Identifier

10.1016/s0015-0282(16)55150-4

Related Literature

Article Analysis
・Side Effects of levonorgestrel
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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