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Treatment of metastatic malignant melanoma with dacarbazine plus tamoxifen.

Author: BellaM, BoniC, BuzziF, CalabresiF, CanalettiR, CeciG, CocconiG, CorgnaE, CostaP, TonatoM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Dacarbazine plus tamoxifen was more effective than dacarbazine alone in treating metastatic malignant melanoma, particularly among women.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Endocrine factors may affect the clinical course of malignant melanoma and the response to the treatment of this disease. The presence of estrogen receptors in melanomas has been suggested, and occasional responses to antiestrogen therapy have been reported. METHODS AND RESULTS: We rand...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM199208203270803

データ提供：米国国立医学図書館（NLM）

A New Path in Melanoma Treatment: Exploring the Potential of Tamoxifen

The fight against cancer is like a battle against the scorching desert sands, requiring a multi-pronged approach. This study delves into the realm of metastatic malignant melanoma, exploring the potential of [研究手法] in combination with existing therapies. The researchers, like skilled desert warriors, embarked on a mission to [主な目的] through a randomized clinical trial. Their findings suggest that [主要な発見] regarding the efficacy of [研究手法] in combination with dacarbazine. The study's findings could potentially lead to new treatment strategies for melanoma, offering a glimmer of hope in the face of this formidable disease. The study's [特筆すべき結果や意義] underscores the importance of considering individual patient characteristics in treatment decisions.

A Potential New Weapon Against Melanoma

This study suggests that [研究結果] might offer a significant benefit for patients with metastatic melanoma. The combination therapy showed a higher response rate and longer survival compared to dacarbazine alone, potentially offering a more effective treatment approach.

Navigating the Sands of Melanoma Treatment

Melanoma, like a desert mirage, can be deceptive. Early detection and consistent monitoring are crucial for successful treatment. This study highlights the importance of exploring new treatment approaches and tailoring therapies to individual patient needs. A holistic approach to health, including a healthy lifestyle, regular check-ups, and informed decision-making, is key to navigating the complexities of melanoma treatment.

Dr.Camel's Conclusion

This study reminds us that the desert of cancer research is vast and full of hidden treasures. The researchers' findings suggest that [研究結果] could be a valuable new weapon in the fight against metastatic melanoma. As we continue to explore the complexities of this disease, we must remain optimistic and committed to finding effective treatments that improve patient outcomes.
Date :
  1. Date Completed 1992-08-25
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

1635566

DOI: Digital Object Identifier

10.1056/NEJM199208203270803

Related Literature

Article Analysis
・Effective treatment of melanoma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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