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[Primary and secondary prevention of cardiovascular events through hormone replacement therapy (HRT)].

Author: PilzHeidemarie

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

The Women's Health Initiative (WHI) trial showed no benefit of hormone replacement therapy (HRT) for heart disease, unlike observational studies. Differences in participant characteristics may explain the discrepancy. A study on HRT for preventing further heart disease after a heart event (secondary prevention) also did not find a benefit overall. However, there was a higher risk of heart disease early in treatment, followed by a lower risk compared to never-using HRT. This suggests that estrogen may have both early risks and later benefits, especially in older women with existing heart disease. Estrogen can affect cholesterol levels, blood vessels, and inflammation in both positive and negative ways. Phytoestrogens, plant-based estrogens, may offer some cardiovascular benefits without increasing triglycerides and may have antioxidant effects. The overall impact of HRT and phytoestrogens on heart disease prevention remains to be conclusively determined.
Paper Details　
Original Abstract of the Article :
A recently (2002) published, randomised, double blind placebo controlled trial of hormone replace ment therapy (HRT), the Women's Health Initiative (WHI), is not consistent with the decrease in cardiovascular disease under CEE/HPA seen in observational primary prevention studies like the Nurses' Hea...See full text at original site
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引用元：
https://doi.org/10.1007/s10354-005-0206-0

データ提供：米国国立医学図書館（NLM）

Hormone Replacement Therapy: A Complex Desert Landscape

Hormone replacement therapy (HRT) is a controversial topic, with research findings often creating a complex and sometimes confusing landscape, like a shifting desert of opinions. This article, like a seasoned guide leading an expedition, explores the potential benefits and risks of HRT for cardiovascular health. It delves into the findings of the Women's Health Initiative (WHI), a landmark study that has significantly impacted the understanding of HRT. The article also examines the use of HRT in secondary prevention of cardiovascular disease and the potential role of phytoestrogens as alternatives to HRT.

HRT and Cardiovascular Health: Navigating the Sands of Evidence

The research on HRT and cardiovascular health is like a complex desert ecosystem, with different studies offering varying perspectives. The WHI study, a major research effort, provided valuable insights into the risks and benefits of HRT, but its findings have also sparked debate. This article provides a nuanced perspective on the evidence, acknowledging the limitations of certain studies and highlighting the need for continued research.

Finding a Balance: Navigating the Risks and Benefits of HRT

The use of HRT for cardiovascular health is a delicate balancing act, like navigating a desert with both fertile oases and dangerous mirages. The article emphasizes the importance of carefully considering the risks and benefits of HRT, taking into account individual factors such as age, medical history, and lifestyle. Just as a traveler would seek advice from experienced guides before venturing into the desert, individuals should consult with healthcare professionals to make informed decisions about HRT.

Dr.Camel's Conclusion

This article provides a comprehensive overview of the complex landscape of HRT and cardiovascular health. It highlights the importance of ongoing research and careful consideration of individual factors when making decisions about HRT. Like a seasoned desert explorer, we must approach HRT with caution, understanding the potential risks and benefits while seeking reliable guidance from healthcare professionals.

Date :
  1. Date Completed 2006-04-13
  2. Date Revised 2019-11-09
Further Info :

Pubmed ID

16392437

DOI: Digital Object Identifier

10.1007/s10354-005-0206-0

SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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