Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish.

Author: PowerDeborah M, VosJosé H, WesterPiet W, van den BrandhofEvert-Jan, van der VenLeo T M

Paper Details 
Original Abstract of the Article :
Some ubiquitous pollutants of the aquatic environment, such as PCBs or other polyhalogenated aromatic hydrocarbons, may disrupt the thyroid hormone system. In a partial life cycle assay with zebrafish (Danio rerio), we studied the effects of the reference compound propylthiouracil (PTU) on reproduct...See full text at original site
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引用元:
https://doi.org/10.1021/es050972c

データ提供:米国国立医学図書館(NLM)

Propylthiouracil: Effects on Zebrafish Development

The delicate balance of the natural world is often disrupted by pollutants, and the consequences can ripple through ecosystems like waves in a desert oasis. This research explores the potential impact of propylthiouracil (PTU), an antithyroid agent, on the development of zebrafish, a model organism commonly used in environmental toxicology studies. The authors conduct a partial life cycle assay to assess the effects of PTU on reproduction, growth, and development, providing valuable insights into the potential toxicity of this compound.

The authors demonstrate that PTU exposure can significantly affect zebrafish development, leading to a range of adverse effects, including dysmorphogenesis, decreased body length, and altered thyroid hormone levels. These findings highlight the potential for PTU to disrupt endocrine function and have negative consequences for aquatic organisms.

PTU: A Potential Threat to Aquatic Organisms

This research highlights the potential toxicity of PTU to aquatic organisms. The study provides valuable insights into the impact of this compound on zebrafish development and underscores the importance of managing environmental pollution to protect the health of aquatic ecosystems.

The Importance of Environmental Protection

The health of our planet and its inhabitants is inextricably linked. This research serves as a reminder of the importance of protecting our environment from pollutants and ensuring the sustainable management of our natural resources.

Dr.Camel's Conclusion

The delicate balance of life in a desert oasis can be easily disrupted, and this research underscores the potential for pollutants like PTU to have detrimental effects on aquatic organisms. The study provides valuable insights into the impact of this compound and highlights the importance of environmental protection for the health of our planet.

Date :
  1. Date Completed 2006-04-17
  2. Date Revised 2019-07-15
Further Info :

Pubmed ID

16433335

DOI: Digital Object Identifier

10.1021/es050972c

Related Literature

SNS
PICO Info
in preparation
Languages

English

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