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A placebo-controlled study of retinal blood flow changes by pentoxifylline and metabolites in humans.

Author: BergstrandIngar C, BjörkmanSven, HeijlAnders, HöglundPeter, MagnussonMarie, RothBodil

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pentoxifylline significantly increased retinal blood flow in humans, and this effect was enhanced by its metabolites R-M1 and M5.
Paper Details　
Original Abstract of the Article :
AIM: To investigate the possible effects of pentoxifylline metabolites on retinal blood flow in humans. METHODS: A randomized, placebo-controlled, four-period cross-over study that was observer blinded and partly blinded for the eight participants. On one occasion a placebo was given as an intraven...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885004/

データ提供：米国国立医学図書館（NLM）

Pentoxifylline and Retinal Blood Flow: A Voyage Through the Vascular System

Pentoxifylline is a medication used to improve blood flow in patients with peripheral vascular disease. This research delves into the effects of pentoxifylline and its metabolites on retinal blood flow. The researchers conducted a placebo-controlled study to investigate the potential influence of pentoxifylline on retinal blood flow and to identify the specific metabolites responsible for its effects.

The Intricate Dance of Pentoxifylline and Retinal Blood Flow

The researchers found that pentoxifylline significantly increased retinal blood flow, and that specific metabolites played a crucial role in this effect. This discovery provides valuable insights into the mechanisms by which pentoxifylline affects the vascular system and could lead to a better understanding of its therapeutic potential.

A Deeper Dive into the Vascular System: Understanding Medication Effects

This research offers a fascinating glimpse into the complex interplay of medications and the vascular system. By understanding the specific effects of pentoxifylline and its metabolites on retinal blood flow, we can gain a deeper appreciation for the intricate processes that govern our vascular health.

Dr.Camel's Conclusion

This study reveals the intricate interplay between pentoxifylline and retinal blood flow, highlighting the importance of specific metabolites in mediating its effects. The findings offer valuable insights for understanding the vascular effects of this medication and may contribute to the development of more targeted therapies for vascular conditions.

Date :
  1. Date Completed 2006-09-21
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

16433868

DOI: Digital Object Identifier

PMC1885004

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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