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Drug withdrawals and the lessons within.

Author: SchmidEsther F, SmithDennis A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review classifies drugs withdrawn from the US market over the last 25 years by their reasons for withdrawal, and examines how drug discovery programs have been modified in response to these events.
Paper Details　
Original Abstract of the Article :
Drug withdrawals over recent decades have triggered changes in the way that drug targets and screening programs are researched and designed. In the cases having the greatest impact, the reason for withdrawal was the reversible interaction of a drug or its metabolite with a single receptor, ion chann...See full text at original site
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/16445116

データ提供：米国国立医学図書館（NLM）

Learning from Drug Withdrawals

The world of drug discovery is a vast desert, filled with trials and tribulations. Researchers are constantly striving to develop new treatments for various ailments. This study takes a retrospective look at drugs that have been withdrawn from the market in recent decades, analyzing the reasons behind these decisions. By understanding the factors leading to drug withdrawals, researchers can refine their drug development strategies and ensure safer, more effective medications for patients.

Improving Drug Development Through Analysis

This research underscores the importance of meticulous drug development and safety assessment. By dissecting the reasons for drug withdrawals, researchers can identify crucial areas for improvement in the drug discovery process. This includes a focus on understanding the complex interactions of drugs with the human body and the potential for adverse effects.

Drug Safety: A Journey Through the Desert of Research

Imagine a traveler navigating a vast desert, encountering unexpected challenges along the way. Similarly, drug development involves navigating a complex landscape, with potential pitfalls and unknowns. This research highlights the importance of careful planning, thorough investigation, and a keen eye for detail in ensuring safe and effective drug development.

Dr. Camel's Conclusion

Drug withdrawals serve as valuable lessons for the pharmaceutical industry, emphasizing the need for rigorous safety assessments and a deep understanding of drug mechanisms. By learning from past mistakes, we can pave the way for safer, more effective treatments, ultimately benefiting patients and improving healthcare outcomes.
Date :
  1. Date Completed 2007-03-28
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

16445116

DOI: Digital Object Identifier

16445116

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Languages

English

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