[Effects of silodosin (KMD-3213) on phenylephrine-induced increase in intraurethral pressure and blood pressure in rats--study of the selectivity for lower urinary tract].

Author: KobayashiKumi, KobayashiMamoru, MaruyamaItaru, ShibataNobuo, TatemichiSatoshi, YamazakiYoshinobu

Paper Details 
Original Abstract of the Article :
The effects of silodosin, an alpha(1A)-adrenoceptor (AR) antagonist, and of other alpha(1)-AR antagonists on the phenylephrine (PE)-induced increase in intraurethral pressure (IUP) and on blood pressure (BP) were studied in anesthetized rats. The drugs were administered intravenously (i.v. study) or...See full text at original site
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引用元:
https://doi.org/10.1248/yakushi.126.217

データ提供:米国国立医学図書館(NLM)

Silodosin: A Selective Oasis in the Desert of Urinary Tract Disorders

This study explores the effects of silodosin, a medication that targets specific receptors in the body, on the urinary tract. It's like navigating a desert landscape, seeking to understand the effects of this medication on specific oases within the body.

The researchers investigated the effects of silodosin on intraurethral pressure and blood pressure in rats, using phenylephrine to induce changes in these parameters. They found that silodosin selectively inhibited the increase in intraurethral pressure without significantly lowering blood pressure. It's like finding a desert oasis that provides water without depleting the surrounding resources.

The study highlights the potential of silodosin as a selective medication for lower urinary tract disorders, targeting specific areas without causing unwanted side effects. It's like finding a path through the desert that leads to the desired oasis without traversing harsh and dangerous terrain.

The Importance of Selectivity in Medication

This study emphasizes the importance of selectivity in medication development, targeting specific areas of the body to minimize side effects. It's like finding a path through the desert that leads to the desired oasis without traversing harsh and dangerous terrain. It encourages researchers to develop medications that are highly specific in their actions, potentially offering more effective and tolerable treatment options.

The Promise of Silodosin for Urinary Tract Disorders

This study presents promising findings for silodosin as a treatment option for lower urinary tract disorders. It's like discovering a hidden oasis in the desert, offering a potential solution for a challenging condition. Continued research is needed to confirm the efficacy and safety of silodosin in humans, potentially leading to a new and effective approach to managing urinary tract disorders.

Dr. Camel's Conclusion

This research sheds light on the potential of silodosin as a selective medication for lower urinary tract disorders, a journey through a desert landscape of intricate biological processes. The study highlights the importance of developing medications that are highly specific in their actions, potentially leading to more effective and tolerable treatments for a variety of conditions.

Date :
  1. Date Completed 2006-05-09
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

16518086

DOI: Digital Object Identifier

10.1248/yakushi.126.217

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