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Advances in pharmacologic agents in imaging: new A2A receptor agonists.

Author: CerqueiraManuel D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Regadenoson and binodenoson, selective adenosine A2A receptor agonists, are being investigated as potential pharmacologic stress agents for myocardial perfusion imaging. These agents offer a safer alternative to dipyridamole and adenosine, with fewer side effects.
Paper Details　
Original Abstract of the Article :
Pharmacologic stress myocardial perfusion imaging is being performed with increasing frequency over exercise stress. Dipyridamole and adenosine have a high side-effect profile, provide higher than needed coronary artery flow rates, and use a relatively complicated method of administration. Based on ...See full text at original site
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引用元：
https://doi.org/10.1007/s11886-006-0022-1

データ提供：米国国立医学図書館（NLM）

Advances in Pharmacologic Agents for Myocardial Perfusion Imaging

Myocardial perfusion imaging (MPI), a technique used to assess blood flow to the heart, has become increasingly reliant on pharmacologic stress, as opposed to exercise stress. This research explores the development of new adenosine A2A receptor agonists, specifically regadenoson, binodenoson, and apadenoson, as potential pharmacologic stress agents.

Exploring New Pharmacologic Stress Agents for Myocardial Perfusion Imaging

The researchers highlight the limitations of existing pharmacologic stress agents, such as dipyridamole and adenosine, and present the potential of new selective adenosine A2A receptor agonists to overcome these limitations. The study showcases the progress in developing safer and more effective pharmacologic stress agents for MPI.

Improving the Safety and Efficacy of Myocardial Perfusion Imaging

The development of these new pharmacologic stress agents could revolutionize MPI, improving the safety and efficacy of this diagnostic tool. This advancement holds promise for enhancing the diagnosis and management of cardiovascular diseases.

Dr.Camel's Conclusion

This research presents an exciting development in the field of myocardial perfusion imaging. The emergence of new selective adenosine A2A receptor agonists offers a potential paradigm shift, paving the way for safer and more effective pharmacologic stress agents, ultimately improving the accuracy and reliability of MPI.
Date :
  1. Date Completed 2007-09-24
  2. Date Revised 2019-11-09
Further Info :

Pubmed ID

16524538

DOI: Digital Object Identifier

10.1007/s11886-006-0022-1

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in preparation
Languages

English

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