Effects of chronic stavudine exposure on liver, pancreas and kidneys of pregnant rats and their fetuses: morphological and biochemical aspects.

Author: BarretoRegina Lúcia Braga, KulayLuiz, MacielGustavo Arantes Rosa, SimõesManuel de Jesus, SimõesRicardo Santos, SoaresJosé Maria

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To study the morphological and biochemical effects on liver, pancreas and kidney of pregnant rats and their fetuses subjected to stavudine treatment. METHODS: Forty animals were distributed in four groups E1, E2, E3, and C (control) and received by gavage once a day 1, 3 or 9 mg/kg of st...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.ejogrb.2005.12.027

データ提供:米国国立医学図書館(NLM)

Stavudine and Pregnancy: Navigating the Desert of Maternal Health

Pregnancy, a delicate journey through the desert of hormonal changes, can be further complicated by the need for medications. This study, like a group of researchers seeking to understand the impact of medications on expectant mothers, examines the effects of chronic stavudine exposure on the liver, pancreas, and kidneys of pregnant rats and their fetuses. Utilizing morphological and biochemical assessments, the researchers delve into the potential risks and benefits of stavudine during pregnancy. Their findings, like a careful examination of the landscape, provide valuable insights into the potential impact of this medication.

Stavudine and Maternal Health: A Balancing Act

The study's findings, like a careful navigation through a treacherous desert, indicate that high doses of stavudine can produce signs of mild to moderate maternal hepatic and pancreatic toxicity at the morphological level. However, the researchers did not observe significant changes in biochemical parameters, suggesting that these organs have a strong functional reserve. This highlights the importance of finding the right balance when it comes to stavudine use during pregnancy, just as a camel needs to carefully manage its water intake to survive in the desert.

Navigating the Sands of Pregnancy: Making Informed Decisions

The study underscores the importance of carefully considering the risks and benefits of medications during pregnancy. Just as a camel needs to be cautious when crossing a desert, so too must expectant mothers and their physicians weigh the potential risks and benefits of medications. Further research is needed to understand the long-term effects of stavudine on maternal and fetal health, but the study's findings provide valuable insights for navigating the complexities of pregnancy and medication use.

Dr. Camel's Conclusion

This research, like a compass guiding us through the desert of pregnancy, offers valuable insights into the potential effects of stavudine on maternal and fetal health. The study's findings highlight the importance of carefully considering the risks and benefits of medications during pregnancy, just as a camel needs to be cautious when venturing into the desert. Further research is needed to understand the long-term effects of stavudine, but the study's results provide valuable information for navigating the complexities of pregnancy and medication use.

Date :
  1. Date Completed 2007-01-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16530920

DOI: Digital Object Identifier

10.1016/j.ejogrb.2005.12.027

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.