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Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics.

Author: AbeKohji, AraiTohko, HasebeNobuyoshi, HoriuchiMasahito, KimuraMegumi, TokumuraMiwa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Beta-lactam antibiotics can induce seizures and neurotoxicity in animals and humans. This study examined the convulsive activity of a new carbapenem antibiotic, doripenem, in various animal models. Imipenem/cilastatin, another carbapenem, induced seizures in rats. Meropenem, another carbapenem, caused mild tremors. However, doripenem did not cause any seizures or behavioral changes. In in vitro studies, doripenem did not inhibit GABA(A) receptor binding, unlike other beta-lactams. These results suggest that doripenem has no convulsive activity and may have negligible neurotoxicity in clinical settings.
Paper Details　
Original Abstract of the Article :
beta-Lactam antibiotics have been suggested to have some degree of convulsive activity and neurotoxicity in experimental animals as well as in clinical situations. We examined the convulsive activities of a new carbapenem antibiotic, (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[[(3S,5S)-...See full text at original site
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引用元：
https://doi.org/10.1016/j.tox.2006.02.004

データ提供：米国国立医学図書館（NLM）

Absence of Convulsive Liability of Doripenem: A New Carbapenem Antibiotic

Carbapenem antibiotics are a crucial class of drugs used to treat bacterial infections, but some have been linked to neurotoxicity and convulsive activity. This study aimed to evaluate the convulsive liability of a new carbapenem antibiotic, doripenem, comparing it to other beta-lactam antibiotics. The researchers conducted a series of animal studies to determine the potential for doripenem to induce seizures.

Doripenem: Navigating the Desert of Antibiotic Safety

The study revealed that doripenem did not induce convulsive activity in any of the animal models tested. In contrast, other beta-lactam antibiotics, such as imipenem and meropenem, showed significant convulsive activity. These findings suggest that doripenem may be a safer option for patients at risk for neurotoxicity, particularly those with pre-existing conditions that could increase their susceptibility to seizures.

Understanding the Landscape of Antibiotic Safety: Minimizing Risks

The study, like a compass guiding us through the vast desert of antibiotic research, provides valuable insights into the safety profile of doripenem. The researchers' findings offer reassurance regarding the potential for doripenem to induce seizures, suggesting that it may be a safer option for patients at risk for neurotoxicity. Continued research and monitoring are essential to ensure the safety of all antibiotics, but this study provides valuable information to guide clinical decision-making.

Dr. Camel's Conclusion

The study's findings provide a reassuring glimpse into the safety profile of doripenem, a new carbapenem antibiotic. The absence of convulsive activity observed in animal models suggests that doripenem may be a safer option for patients at risk for neurotoxicity. As we continue to explore the desert of antibiotic research, we must remain vigilant in our pursuit of safe and effective treatments for bacterial infections.
Date :
  1. Date Completed 2006-06-08
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

16549226

DOI: Digital Object Identifier

10.1016/j.tox.2006.02.004

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Languages

English

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