Comparison of regimes of treatment of antimony-resistant kala-azar patients: a randomized study.

Author: KumarM, PandeyA K, ThakurC P

Paper Details 
Original Abstract of the Article :
Three hundred twelve patients with antimony-resistant kala-azar were randomized into three groups. The first group (A) received pentamidine isethionate intravenously three times each week until parasitological cure was achieved. Group B received pentamidine concomitantly with a 20-day regimen of sod...See full text at original site
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引用元:
https://doi.org/10.4269/ajtmh.1991.45.435

データ提供:米国国立医学図書館(NLM)

Antimony-Resistant Kala-azar: A Challenging Battlefield for Treatment

Kala-azar, a life-threatening parasitic disease, presents a formidable challenge for healthcare providers. The emergence of antimony resistance has further complicated treatment, necessitating the search for alternative therapies. This study explores the effectiveness of pentamidine isethionate, an alternative treatment option, in patients with antimony-resistant kala-azar.

The study compared three different treatment regimens involving pentamidine isethionate, either alone or in combination with sodium stibogluconate. The researchers found that pentamidine was effective in achieving parasitological cure in most patients, with a high cure rate observed after multiple injections. However, the study also revealed that pentamidine can cause significant side effects, including hyperglycemia, hypoglycemia, and even death in some cases.

This study provides valuable information on the effectiveness and safety of pentamidine isethionate for treating antimony-resistant kala-azar. It highlights the importance of careful monitoring and judicious use of this potentially toxic drug, emphasizing the need for further research to develop safer and more effective treatment options for this challenging disease.

Navigating the Toxic Terrain of Kala-azar Treatment

This study is like a camel caravan navigating through a treacherous desert of kala-azar, searching for an effective antidote to the disease. The researchers, armed with their knowledge and skills, sought a cure amidst the harsh realities of antimony resistance. Their journey unveils the complexities of treating this challenging disease, emphasizing the need for caution and further research.

The Importance of Vigilance in Infectious Disease Treatment

This research underscores the importance of vigilance in treating infectious diseases. The emergence of drug resistance highlights the need for constant monitoring and the development of new therapeutic strategies to combat these evolving threats.

Dr.Camel's Conclusion

The research on antimony-resistant kala-azar is like a camel caravan traversing a desolate desert of parasitic infections. It reveals the challenges of treating this challenging disease and the need for alternative therapies. The study's findings emphasize the importance of careful monitoring and further research to develop safer and more effective treatment options for kala-azar.

Date :
  1. Date Completed 1991-12-10
  2. Date Revised 2019-05-16
Further Info :

Pubmed ID

1659239

DOI: Digital Object Identifier

10.4269/ajtmh.1991.45.435

Related Literature

SNS
PICO Info
in preparation
Languages

English

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