Polyethylene glycol 4000 vs. lactulose for the treatment of neurogenic constipation in myelomeningocele children: a randomized-controlled clinical trial.

Finding Relief for Neurogenic Constipation in Children: Polyethylene Glycol vs. Lactulose

Neurogenic constipation, a condition often affecting children with myelomeningocele, can be a significant challenge. This study compares the effectiveness and tolerability of two commonly used treatments, polyethylene glycol 4000 and lactulose, in alleviating constipation in this population. The researchers conducted a randomized controlled trial, finding that polyethylene glycol 4000 was significantly more effective in improving bowel frequency and reducing constipation symptoms compared to lactulose.

Polyethylene Glycol 4000: A Promising Solution for Neurogenic Constipation

The study revealed that polyethylene glycol 4000, administered at a dose of 0.50 g/kg daily, was significantly more successful in treating neurogenic constipation compared to lactulose. Nearly half of the children receiving polyethylene glycol 4000 experienced complete remission of their constipation symptoms, compared to only 22% in the lactulose group. Furthermore, polyethylene glycol 4000 was associated with a higher bowel frequency and a reduction in encopresis, a condition characterized by fecal incontinence.

Addressing Constipation in Children with Myelomeningocele: A Focus on Safety

This research offers valuable insights into the treatment of neurogenic constipation in children with myelomeningocele. While polyethylene glycol 4000 appears to be a more effective option, it's important to remember that every child is unique, and individual responses to treatment can vary. It's crucial to consult with a healthcare professional to determine the most appropriate treatment plan for each child.

Dr.Camel's Conclusion

Like a camel navigating a winding desert path, finding the right treatment for neurogenic constipation can feel like a journey with unexpected twists and turns. This research sheds light on a potential solution, suggesting that polyethylene glycol 4000 may provide a smoother and more effective path to relief. Remember, every journey requires careful planning and a personalized approach, ensuring that the path chosen is the safest and most effective for reaching the desired destination.