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LL-37 protects rats against lethal sepsis caused by gram-negative bacteria.

Author: BergnachCristina, CirioniOscar, GhiselliRoberto, GiacomettiAndrea, LicciAlberto, MocchegianiFederico, OrlandoFiorenza, RocchiMarco, SabaVittorio, ScaliseGiorgio, SilvestriCarmela, SkerlavajBarbara, ZanettiMargherita

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

LL-37, a human cationic antimicrobial protein, demonstrated effectiveness in three experimental rat models of gram-negative sepsis, reducing lethality and bacterial growth. LL-37 was comparable to polymyxin B in antimicrobial and antiendotoxin activities and showed promising results as a potential treatment for sepsis.
Paper Details　
Original Abstract of the Article :
We investigated the efficacy of LL-37, the C-terminal part of the only cathelicidin in humans identified to date (termed human cationic antimicrobial protein), in three experimental rat models of gram-negative sepsis. Adult male Wistar rats (i) were given an intraperitoneal injection of 1 mg Escheri...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472226/

データ提供：米国国立医学図書館（NLM）

LL-37: A New Weapon Against Sepsis

Imagine a camel caravan facing a sudden attack by a swarm of desert locusts. Sepsis is a life-threatening infection that can occur when the body's immune system overreacts to an infection. This study investigates the potential of LL-37, a human antimicrobial protein, as a treatment for sepsis caused by gram-negative bacteria. It's like seeking a natural remedy from the desert's vast arsenal of resources, hoping to protect the caravan from a deadly threat.

This research explores the efficacy of LL-37 in three experimental rat models of gram-negative sepsis. It's like studying the defense mechanisms of a desert creature, understanding how this protein can combat infection. The authors find that LL-37 is effective in reducing lethality, bacterial growth, and inflammatory responses in these models, highlighting its potential as a therapeutic agent for sepsis.

A Natural Ally: LL-37 in the Fight Against Sepsis

This study suggests that LL-37 may be a promising treatment option for sepsis caused by gram-negative bacteria. It highlights the potential for LL-37 to reduce lethality, bacterial growth, and inflammatory responses. It's like discovering a new oasis in the desert, offering a refuge from the dangers of sepsis.

Confronting the Desert Storm: Seeking Protection from Sepsis

This research underscores the importance of exploring new treatment options for sepsis. It emphasizes the need for continued research to develop effective therapies for this life-threatening condition. It's like a camel caravan navigating a desert storm, seeking shelter and protection from the elements.

Dr. Camel's Conclusion

This study explores the potential of LL-37 as a treatment for sepsis. It's a reminder that nature holds many hidden treasures, and that by studying the natural world, we can find new ways to combat disease. It's a journey through the desert of medical research, seeking solutions and finding hope for a healthier future.

Date :
  1. Date Completed 2006-06-09
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

16641434

DOI: Digital Object Identifier

PMC1472226

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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