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Human ether-a-go-go-related (HERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects.

Author: ZünklerBernd J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Many drugs can prolong the QT interval and increase the risk of Torsades de pointes arrhythmia. These drugs block the HERG channel, a potassium channel important for cardiac repolarization. Sulfonylureas and glinides block the KATP channel, which is involved in insulin secretion and may have cardiotoxic or cardioprotective effects during cardiac ischemia.
Paper Details　
Original Abstract of the Article :
Torsades de pointes (TdP) arrhythmia is a potentially fatal form of ventricular arrhythmia that occurs under conditions where cardiac repolarization is delayed (as indicated by prolonged QT intervals from electrocardiographic recordings). A likely mechanism for QT interval prolongation and TdP arrhy...See full text at original site
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引用元：
https://doi.org/10.1016/j.pharmthera.2006.03.002

データ提供：米国国立医学図書館（NLM）

The Heart's Electrical Symphony: A Camel's Journey Through Cardiac Channels

This study delves into the complex world of cardiac ion channels, exploring their role in the heart's electrical activity and the potential for drug-induced disruptions. The researchers focus on two critical channels: the human ether-a-go-go-related gene (HERG) channel and the ATP-sensitive potassium (KATP) channel. They discuss the potential of HERG channel blockers to cause QT interval prolongation and Torsades de pointes (TdP) arrhythmias, a potentially fatal form of ventricular arrhythmia.

A Camel's Beat: The Interplay of Channels and Drugs

This study highlights the delicate balance of cardiac ion channels and the potential for drugs to disrupt this balance. The researchers emphasize the importance of understanding the potential for drug-induced QT interval prolongation and TdP arrhythmias.

The Camel's Wisdom on Heart Health: Navigating Medications Safely

This study underscores the importance of careful medication use, particularly when it comes to drugs that can affect the heart's electrical activity. It encourages patients to discuss any concerns they may have about potential side effects with their healthcare providers.

Dr. Camel's Conclusion

Just as a camel's heart beats steadily in the desert's heat, maintaining a healthy heart requires a delicate balance. This study delves into the complex world of cardiac ion channels, reminding us of the potential for drug-induced disruptions and the importance of making informed decisions about our medication use.

Date :
  1. Date Completed 2007-01-10
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

16647758

DOI: Digital Object Identifier

10.1016/j.pharmthera.2006.03.002

SNS
PICO Info
in preparation
Languages

English

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