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Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension.

Author: MeckJanice V, PlattsSteven H, WatersWendy W, ZieglerMichael G

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Orthostatic hypotension and presyncope are common and potentially serious risks for astronauts returning from space. This study tested the hypothesis that midodrine would have no negative hemodynamic effect on healthy astronauts returning from space.
Paper Details　
Original Abstract of the Article :
Orthostatic hypotension and presyncope are common and potentially serious risks for astronauts returning from space. Susceptible subjects fail to generate an adequate adrenergic response to upright posture. The alpha-1 adrenergic agonist, midodrine, may be an effective countermeasure. We tested the ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/16676655

データ提供：米国国立医学図書館（NLM）

Midodrine: A Potential Countermeasure for Orthostatic Hypotension After Spaceflight

Spaceflight presents unique physiological challenges, including orthostatic hypotension, a condition where blood pressure drops upon standing. This study investigates the potential use of midodrine, an alpha-1 adrenergic agonist, as a countermeasure for orthostatic hypotension in astronauts returning from space. The research evaluated the hemodynamic effects of midodrine in healthy astronauts, seeking to determine its safety and effectiveness in mitigating this spaceflight-related issue. It's like venturing into the vast and unknown cosmos, seeking to understand the effects of spaceflight on the human body and developing strategies to protect astronaut health.

Midodrine: A Promising Countermeasure for Spaceflight-Related Issues

This study found that midodrine had no negative hemodynamic effects on healthy astronauts returning from space, suggesting its potential as a safe and effective countermeasure for orthostatic hypotension. It's like finding a reliable oasis in the harsh desert of spaceflight, providing relief and support for astronauts as they navigate the challenges of space travel.

The Human Body in Space: A Journey Through the Cosmic Desert

The human body is an incredible machine, but it faces unique challenges when venturing beyond the Earth's atmosphere. This study highlights the importance of understanding the effects of spaceflight on the human body and developing strategies to protect astronaut health. It's a reminder to approach the cosmic desert with respect and caution, ensuring the safety and well-being of our explorers.

Dr.Camel's Conclusion

This study offers a glimmer of hope for astronauts facing orthostatic hypotension after spaceflight. It underscores the importance of continuous research and development of effective countermeasures, ensuring the safety and well-being of our intrepid space travelers as they explore the vast and unforgiving cosmic desert.

Date :
  1. Date Completed 2006-09-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16676655

DOI: Digital Object Identifier

16676655

Related Literature

Article Analysis
・Effects of midodrine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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