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Bioequivalence of liquid and reconstituted lyophilized etanercept subcutaneous injections.

Author: NiLiyun, PelosoPaul M, SalfiMargaret, SheeloClaudia, SullivanJohn T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the pharmacokinetics of liquid and reconstituted lyophilized etanercept. The liquid formulation was found to be bioequivalent to the reconstituted lyophilized formulation.
Paper Details　
Original Abstract of the Article :
The objective of this study was to compare the pharmacokinetics of liquid and reconstituted lyophilized etanercept. This single-center, open-label study had a 2-period crossover design in which 36 healthy subjects were randomly assigned in a 1:1 ratio to etanercept (liquid/lyo or lyo/liquid). The tr...See full text at original site
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引用元：
https://doi.org/10.1177/0091270006287705

データ提供：米国国立医学図書館（NLM）

Liquid vs. Reconstituted Etanercept: A Comparative Study

This research investigates the bioequivalence of two different formulations of etanercept, a medication used to treat autoimmune diseases. The study compared the pharmacokinetics of liquid etanercept with reconstituted lyophilized etanercept, analyzing serum drug concentration-time profiles in healthy volunteers. The findings demonstrate that the two formulations are bioequivalent, meaning they produce similar concentrations of etanercept in the body.

Bioequivalence Confirmed

The study confirms that liquid etanercept is bioequivalent to reconstituted lyophilized etanercept. This finding provides reassurance for healthcare professionals and patients, indicating that both formulations can be used interchangeably without compromising efficacy or safety.

Navigating the Landscape of Medication Delivery

This research underscores the importance of rigorous testing to ensure bioequivalence between different formulations of medications. The study highlights the need for careful evaluation of drug delivery methods to ensure consistent and reliable therapeutic effects. Just as a camel navigates the desert landscape with a keen sense of direction, researchers are dedicated to ensuring the safe and effective delivery of medications to patients.

Dr. Camel's Conclusion

The study confirms the bioequivalence of liquid and reconstituted etanercept, providing valuable information for healthcare professionals and patients alike.

Date :
  1. Date Completed 2006-11-06
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

16707412

DOI: Digital Object Identifier

10.1177/0091270006287705

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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