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The effects of sulfasalazine metabolites on hemoglobin-catalyzed lipid peroxidation.

Author: GrishamM B, VolkmerC, YamadaT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Sulfasalazine (SAZ) and its metabolite 5-aminosalicylic acid (5-ASA) were tested for their ability to inhibit lipid peroxidation, a process that contributes to inflammation in ulcerative colitis. 5-ASA was significantly better than SAZ at inhibiting lipid peroxidation, suggesting that 5-ASA may play a role in the anti-inflammatory effects of SAZ.
Paper Details　
Original Abstract of the Article :
Ulcerative colitis (UC) is a recurrent inflammation of the colon and rectum that is characterized by subepithelial hemorrhage, epithelial cell necrosis, infiltration of large numbers of phagocytic leukocytes (neutrophils, eosinophils, macrophages), and mucosal ulcerations. Recent evidence suggests t...See full text at original site
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引用元：
https://doi.org/10.1016/0891-5849(91)90020-4

データ提供：米国国立医学図書館（NLM）

Sulfasalazine Metabolites and Ulcerative Colitis: A Journey Through Inflammation

Ulcerative colitis, a chronic inflammatory bowel disease, can feel like a raging desert storm, causing discomfort and inflammation in the digestive tract. This research delves into the mechanisms by which sulfasalazine, a medication commonly used to treat ulcerative colitis, works to combat inflammation.

Understanding Sulfasalazine's Action

This research investigates the role of sulfasalazine metabolites, particularly 5-aminosalicylic acid (5-ASA), in inhibiting lipid peroxidation, a process that contributes to inflammation. The study demonstrates that 5-ASA is significantly more effective than the parent compound, sulfasalazine, in reducing lipid peroxidation.

Potential for Anti-Inflammatory Therapies

This research sheds light on the potential of 5-ASA, a key metabolite of sulfasalazine, as a potent anti-inflammatory agent. It provides valuable insights into the mechanisms underlying the drug's effectiveness in managing ulcerative colitis.

Dr.Camel's Conclusion

This research explores the intricate mechanisms of sulfasalazine and its metabolites in combating ulcerative colitis. It highlights the importance of understanding these mechanisms to develop more effective anti-inflammatory therapies for this challenging condition.

Date :
  1. Date Completed 1991-07-22
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

1675620

DOI: Digital Object Identifier

10.1016/0891-5849(91)90020-4

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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