Efficacy and safety of the six-dose regimen of artemether-lumefantrine in pediatrics with uncomplicated Plasmodium falciparum malaria: a pooled analysis of individual patient data.

Author: AndrianoKim, De PalaciosPatricia Ibarra, FaladeCatherine, HuntPhilip, KarbwangJuntra, MakangaMichael, MuellerEdgar A, PremjiZul

Paper Details 
Original Abstract of the Article :
Patient data from eight clinical trials were pooled and analyzed to study the efficacy and safety of the six-dose versus four-dose regimen of artemether-lumefantrine (coartemether; Coartem) in children weighing 5-25 kg. A total of 544 patients with uncomplicated P. falciparum malaria (six-dose: 343;...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/16760509

データ提供:米国国立医学図書館(NLM)

Artemether-Lumefantrine: A Six-Dose Regimen for Uncomplicated Malaria in Children

This study explores the fight against malaria, a deadly disease that affects millions worldwide. It's like navigating a vast and unforgiving desert, where the right tools and strategies are crucial for survival.

The researchers investigated the efficacy and safety of a six-dose regimen of artemether-lumefantrine (Coartem) for treating uncomplicated Plasmodium falciparum malaria in children. Their findings are like discovering a hidden oasis in the desert of malaria treatments, suggesting that the six-dose regimen is more effective than the four-dose regimen. The study found that the six-dose regimen achieved significantly higher cure rates compared to the four-dose regimen, particularly in non-immune infants.

This study offers valuable insights into the treatment of malaria in children. It emphasizes the importance of finding effective and safe treatments that are tailored to the specific needs of young patients. The findings suggest that the six-dose regimen of Coartem may be a more reliable and robust treatment option for uncomplicated malaria in children.

Six-Dose Regimen: A More Effective Treatment for Malaria

This study shows that a six-dose regimen of artemether-lumefantrine is more effective and safe than the four-dose regimen for treating uncomplicated Plasmodium falciparum malaria in children. The findings suggest that the six-dose regimen may be a more reliable and robust treatment option, particularly for non-immune infants.

Dr. Camel's Conclusion

This research reminds us that the fight against malaria is a constant battle, requiring a relentless pursuit of effective treatments. It highlights the importance of finding innovative solutions that can protect vulnerable populations, like children, from the devastating effects of this disease. The findings suggest that a six-dose regimen of Coartem could be a valuable tool in the arsenal of malaria treatment, offering a better chance of survival and a brighter future for those affected.

Date :
  1. Date Completed 2006-07-20
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

16760509

DOI: Digital Object Identifier

74/6/991

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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