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Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype.

Author: ArnstenA F, LeslieF M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

UK-14304 is an alpha 2-agonist that has been shown to improve memory in aged monkeys. The drug has a slightly higher affinity for the Ri than the Rs site.
Paper Details　
Original Abstract of the Article :
The ability of the alpha 2-agonists clonidine, B-HT920 (6-allyl-2-amino-5,6,7,8-tetrohydro-4H-thiazolo-[4,5-d]-azepine) and guanfacine to improve memory in aged monkeys has been related to their affinity to bind at a proposed rauwolscine-insensitive (Ri) subtype of alpha 2-adrenergic receptor, while...See full text at original site
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引用元：
https://doi.org/10.1016/0028-3908(91)90024-6

データ提供：米国国立医学図書館（NLM）

Alpha 2-Adrenergic Agonist UK-14304 and Cognitive Enhancement

This study investigates the cognitive enhancing effects of UK-14304, an alpha 2-adrenergic agonist, in aged monkeys. It’s like uncovering a hidden oasis in the desert, revealing a potential source of rejuvenation. The research focuses on the binding characteristics of UK-14304 and its behavioral effects, particularly its ability to improve memory in aged monkeys. The study findings suggest that UK-14304 may have potential for treating age-related cognitive decline.

Cognitive Enhancement with UK-14304

The study demonstrated that low doses of UK-14304 significantly improved memory in aged monkeys without causing hypotensive or sedating side effects. It’s like finding a gentle breeze in a scorching desert, providing a refreshing respite without disrupting the delicate balance of the environment. The researchers concluded that UK-14304 may be a promising candidate for the development of new treatments for age-related cognitive decline.

Implications for Cognitive Function

This research provides a glimmer of hope for individuals seeking to improve cognitive function as they age. It’s like finding a hidden path leading to a fertile valley in the desert, offering a potential solution to a challenging problem. The study findings suggest that UK-14304 may have therapeutic potential for age-related cognitive decline, opening new avenues for research and development in this important area.

Dr.Camel's Conclusion

This study explores the potential of UK-14304, an alpha 2-adrenergic agonist, for improving cognitive function in aged individuals. It’s like discovering a hidden spring in the desert, providing a source of renewal and vitality. The study findings suggest that UK-14304 may offer a promising approach to addressing age-related cognitive decline, opening new avenues for research and development in this critical area.

Date :
  1. Date Completed 1992-03-24
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

1686301

DOI: Digital Object Identifier

10.1016/0028-3908(91)90024-6

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English

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