Paper Details

  1. Home
  2. Paper Details

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

Author: AmeliRezvan, BrutscheNancy E, CarlsonPaul J, CharneyDennis S, LuckenbaughDavid A, ManjiHusseini K, SinghJaskaran B, ZarateCarlos A

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Overview

The study discussed the need for pharmacological strategies with rapid onset of antidepressant effects, highlighting the potential role of the glutamatergic system in the pathophysiology and treatment of mood disorders.
Paper Details　
Original Abstract of the Article :
Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset of antidepressant effects within a few days and that are sustained would have an enormous impact on patient care. Co...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1001/archpsyc.63.8.856

データ提供：米国国立医学図書館（NLM）

The Quest for Rapid Antidepressant Action

The search for effective treatments for major depression is like exploring a vast desert landscape, seeking a hidden oasis of relief. This research delves into the potential of an N-methyl-D-aspartate (NMDA) antagonist to provide rapid relief from depression. Currently, many treatments take weeks to show results, leading to prolonged suffering. The researchers are looking for ways to speed up the healing process and bring about a quicker oasis of relief. Their research focuses on the glutamatergic system, a crucial part of the brain's communication network, and its role in both the development and treatment of mood disorders.

Unlocking the Secrets of the Brain

This research aims to understand how the glutamatergic system influences depression and how we can manipulate this system to achieve faster and more effective treatments. The findings could lead to new and innovative approaches to managing depression, bringing hope to those who have been struggling.

Understanding Depression's Landscape

This research reminds us that depression is a complex condition with a vast and intricate landscape. The exploration of the glutamatergic system offers promising pathways for developing faster-acting and more effective treatments. It's crucial to remember that every individual's journey through depression is unique, and finding the right treatment is a personal quest.

Dr. Camel's Conclusion

This research focuses on the potential of NMDA antagonists for rapid antidepressant action. This could be a game-changer for individuals struggling with depression, offering a faster path to relief. The study highlights the importance of understanding the intricate workings of the brain and the potential for developing targeted treatments. Remember, if you are experiencing depression, seeking professional help is essential to navigate this challenging landscape and find the support you need.
Date :
  1. Date Completed 2006-09-01
  2. Date Revised 2022-04-19
Further Info :

Pubmed ID

16894061

DOI: Digital Object Identifier

10.1001/archpsyc.63.8.856

Related Literature

Article Analysis
・Effective treatment of mood disorders
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.