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Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockers.

Author: ChengHuifang, HarrisRaymond C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Angiotensin II plays a crucial role in the development of hypertension, cardiovascular, and renal injury. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers effectively control blood pressure, minimize left ventricular remodeling, prevent heart failure, and reduce proteinuria and renal disease progression. While generally safe, concerns exist about their potential side effects in certain populations. Novel, low molecular weight renin inhibitors, with favorable pharmacokinetic properties, have shown promise in reducing Ang II levels and lowering blood pressure.
Paper Details　
Original Abstract of the Article :
Angiotensin (Ang) II plays important roles in the development of hypertension and cardiovascular and renal injury. Pharmaceutical approaches to block its activity led to the development of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Numerous trials have documented the...See full text at original site
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引用元：
https://doi.org/10.1517/14740338.5.5.631

データ提供：米国国立医学図書館（NLM）

Renin Inhibitors: Exploring a New Oasis in the Desert of Hypertension

Hypertension, a silent killer, is a vast desert of cardiovascular risk. This review delves into the world of renin inhibitors, a new class of drugs that target the renin-angiotensin system, a crucial regulator of blood pressure. The authors provide a comprehensive overview of these novel drugs, exploring their potential benefits and safety profile.

Renin Inhibitors: A New Path Through the Desert of Hypertension

The review highlights the growing interest in renin inhibitors as a new therapeutic option for managing hypertension. The authors emphasize the favorable pharmacokinetic properties of these drugs, which offer advantages over traditional renin-angiotensin blockers. The review underscores the need for continued research to fully understand the long-term efficacy and safety of renin inhibitors, ensuring their safe and effective application in the management of hypertension.

Navigating the Desert of Hypertension: Understanding Renin Inhibitors

This research is a valuable contribution to our understanding of renin inhibitors and their potential role in managing hypertension. The review provides a comprehensive overview of this new class of drugs, highlighting their mechanisms of action, pharmacokinetic properties, and potential benefits. This research is a crucial step towards expanding our therapeutic arsenal for managing hypertension, a condition that affects millions worldwide.

Dr.Camel's Conclusion

The review of renin inhibitors is like finding a new oasis in the desert of hypertension. It reveals the potential of this new class of drugs to offer a more effective and safe approach to managing blood pressure. This research is a crucial step towards developing more targeted and personalized treatments for hypertension, a critical endeavor for improving the health and well-being of those affected by this condition.

Date :
  1. Date Completed 2006-08-23
  2. Date Revised 2019-11-10
Further Info :

Pubmed ID

16907653

DOI: Digital Object Identifier

10.1517/14740338.5.5.631

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English

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