Paper Details

  1. Home
  2. Paper Details

CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine.

Author: ArnethB, DragicevicA, HiemkeC, HärtterS, KaiserR, LacknerK, MüllerM J, ShamsM E E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Venlafaxine, a mixed serotonin and noradrenaline reuptake inhibitor, is metabolized by the cytochrome P450 (CYP) enzyme CYP2D6 to yield an active metabolite, O-desmethylvenlafaxine.
Paper Details　
Original Abstract of the Article :
Venlafaxine (V) is a mixed serotonin and noradrenaline reuptake inhibitor used as a first-line treatment of depressive disorders. It is metabolized primarily by the highly polymorphic cytochrome P450 (CYP) enzyme CYP2D6 to yield a pharmacologically active metabolite, O-desmethylvenlafaxine (ODV), an...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1365-2710.2006.00763.x

データ提供：米国国立医学図書館（NLM）

The Intricate Dance of Venlafaxine Metabolism

The realm of antidepressant pharmacology is as complex as a sandstorm, with countless factors influencing the efficacy and safety of treatment. This study investigates the role of CYP2D6 polymorphism in the metabolism of venlafaxine, a widely used antidepressant. The authors delve into the intricate mechanisms by which CYP2D6 influences the conversion of venlafaxine into its active metabolite, O-desmethylvenlafaxine (ODV).

Tailoring Treatment Based on Genetic Variations

This research highlights the significance of individual genetic variations in determining drug metabolism and response. The authors emphasize the importance of considering CYP2D6 genotype when prescribing venlafaxine. Understanding the impact of genetic variations on drug metabolism can help tailor treatment regimens to optimize efficacy and minimize potential adverse reactions.

Personalized Medicine: Navigating the Sands of Individuality

Just as the desert has diverse landscapes, so too do individuals respond differently to medication. This study underscores the need for personalized medicine, where treatment strategies are tailored to individual genetic profiles. The authors advocate for incorporating genetic testing into clinical practice, paving the way for more targeted and effective therapies.

Dr.Camel's Conclusion

This study reminds us that the sands of the desert of pharmacology are constantly shifting, demanding a flexible and personalized approach to treatment. We must learn to navigate the intricate pathways of drug metabolism, recognizing the unique genetic landscapes of each individual. This knowledge empowers us to optimize treatment strategies and improve patient outcomes in the vast desert of mental health care.

Date :
  1. Date Completed 2006-12-15
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

16958828

DOI: Digital Object Identifier

10.1111/j.1365-2710.2006.00763.x

Related Literature

Article Analysis
・Side Effects of desvenlafaxine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.