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Comparison of the skeletal effects of the progestogens desogestrel and levonorgestrel in oral contraceptive preparations in young women: controlled, open, partly randomized investigation over 13 cycles.

Author: EggerKathrin, ErbenReinhold G, FelsenbergDieter, HartardManfred, KleinmondChristine, LuppaPeter, WeissenbacherErnst Rainer, WisemanMichael, ZelgerOtto

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the skeletal effects of two monophasic oral contraceptives containing 20 mug of ethinylestradiol and 100 mug of levonorgestrel (LEVO) or 150 mug of desogestrel (DESO) in young women. The results showed that the LEVO group did not lose vertebral bone mineral density (BMD), whereas women in the DESO group lost 1.5%. LEVO also induced an increase in total cross-sectional area at the distal radius and tibia, suggesting increased periosteal bone formation. The study concluded that the skeletal effects of oral contraceptives may be influenced by progestogenic components in young women.
Paper Details　
Original Abstract of the Article :
AIM: This 12-month study was conducted to evaluate the skeletal effects of two monophasic oral contraceptives containing 20 mug of ethinylestradiol and 100 mug of levonorgestrel (LEVO) or 150 mug of desogestrel (DESO). METHODS: Fifty-two women (18-24 years) were randomized into the DESO group or th...See full text at original site
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引用元：
https://doi.org/10.1016/j.contraception.2006.06.005

データ提供：米国国立医学図書館（NLM）

Skeletal Effects of Progestogens in Oral Contraceptives

Oral contraceptives (OCs) are commonly used for contraception, but their long-term effects on bone health remain a subject of research. This study investigates the skeletal effects of two different progestogens, desogestrel and levonorgestrel, in OC preparations. The researchers conducted a 12-month study involving 52 young women, comparing the effects of OCs containing desogestrel or levonorgestrel on bone mineral density (BMD) and bone geometry.

The Influence of Progestogens: Understanding Skeletal Changes

The study found that women in the desogestrel group experienced a slight decrease in vertebral BMD, while women in the levonorgestrel group did not. Levonorgestrel was also associated with increased periosteal bone formation at the distal radius and tibia. These findings suggest that different progestogens may have varying effects on bone health.

Navigating the Desert of Bone Health: Choosing the Right OC

The desert of hormonal health is vast and complex, and choosing the right OC can be a challenge. This study highlights the importance of considering the potential skeletal effects of different progestogens. Women who are concerned about bone health may want to discuss their options with their healthcare provider and choose an OC that minimizes potential negative effects on bone.

Dr. Camel's Conclusion

This study takes us on a journey through the complexities of hormonal health and bone metabolism. The findings suggest that different progestogens in OCs can have distinct effects on bone health, highlighting the importance of understanding these nuances. This study emphasizes the need for ongoing research to further investigate the long-term skeletal effects of different OC formulations and provide women with more informed choices for managing their reproductive health.

Date :
  1. Date Completed 2007-01-11
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17046377

DOI: Digital Object Identifier

10.1016/j.contraception.2006.06.005

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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