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Grapefruit juice and drug interactions. Exploring mechanisms of this interaction and potential toxicity for certain drugs.

Author: BresslerRubin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Grapefruit juice can significantly alter the plasma concentrations of numerous drugs by inhibiting CYP3A4 and OATP enzymes, leading to potentially adverse clinical effects. It is essential to advise patients about potential interactions with grapefruit juice and certain medications.
Paper Details　
Original Abstract of the Article :
Concomitant administration of grapefruit juice can increase the plasma concentration of numerous drugs in humans and decrease the concentration of a few others. Such elevations of drug plasma concentrations have, on occasion, resulted in adverse clinical effects. Increased concentrations are primari...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/17112309

データ提供：米国国立医学図書館（NLM）

Grapefruit Juice: A Hidden Danger for Drug Interactions

This research takes us on a journey through the world of drug interactions, highlighting the potential risks associated with consuming grapefruit juice alongside certain medications. The study explores the mechanisms by which grapefruit juice can significantly alter the metabolism of numerous drugs, leading to potential adverse clinical effects. The researchers explain how grapefruit juice inhibits a key enzyme in the small intestines, CYP 3A4, which plays a crucial role in drug metabolism. This inhibition can increase drug bioavailability and plasma concentrations, potentially leading to unintended consequences. The study also discusses the impact of grapefruit juice on other drug transporters, highlighting the importance of caution when consuming this popular beverage alongside medications.

Grapefruit Juice and Drug Interactions: A Cautionary Tale

The study reveals the significant impact of grapefruit juice on drug metabolism, emphasizing the need for careful consideration when consuming this beverage alongside medications. This research highlights the importance of consulting with a healthcare provider to avoid potential adverse interactions and ensure safe and effective drug therapy.

Navigating Grapefruit Juice and Medications: A Practical Guide

Individuals taking medications should be aware of the potential for drug interactions with grapefruit juice. Consulting with a healthcare provider is crucial to identify any potential risks and ensure safe drug use. Remember, a little caution can go a long way in maintaining your health and well-being.

Dr.Camel's Conclusion

Grapefruit juice, a seemingly harmless beverage, can hold hidden dangers for those taking medications. This research is a reminder that even seemingly innocuous substances can significantly impact drug metabolism, potentially leading to adverse effects. Like a wise traveler carefully choosing their path through the desert, we must be mindful of potential interactions to ensure a safe and successful journey.
Date :
  1. Date Completed 2006-12-19
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

17112309

DOI: Digital Object Identifier

17112309

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