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A randomized controlled trial of cetirizine plus pseudoephedrine versus loratadine plus pseudoephedrine for perennial allergic rhinitis.

Author: ChenTien-Ling, ChiangYi-Chi, HuangLi-Hsin, KaoYu-Hsuan, LiangPei-Hsuan, LinMao-Tsair, ShyurShyh-Dar, WangTsung-Chi, WenTa-Chzng, YangHwai-Chih

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This double-blind, randomized, parallel trial compared the efficacy and safety of cetirizine plus pseudoephedrine (C+P) with loratadine plus pseudoephedrine (L+P) in treating perennial allergic rhinitis. Both medications were effective, with C+P showing slightly better relief of sneezing and nasal congestion and slightly better tolerability.
Paper Details　
Original Abstract of the Article :
The purpose of this study was to compare the safety and efficacy of cetirizine plus pseudoephedrine (C+P) with loratadine plus pseudoephedrine (L+P) in the treatment of perennial allergic rhinitis. This was a double blind, randomized, parallel trial with an active control. Subjects aged 12 to 70 yea...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/17136873

データ提供：米国国立医学図書館（NLM）

Cetirizine Plus Pseudoephedrine Versus Loratadine Plus Pseudoephedrine for Perennial Allergic Rhinitis

This research investigates the comparative efficacy and safety of two common antihistamine combinations, cetirizine plus pseudoephedrine (C+P) and loratadine plus pseudoephedrine (L+P), in treating perennial allergic rhinitis. The authors conducted a double-blind, randomized, parallel trial with an active control, comparing the symptom relief provided by each medication combination over a four-week period. Their findings suggest that both combinations are effective in reducing allergic rhinitis symptoms, with C+P potentially offering slightly better relief of sneezing and nasal congestion.

Alleviating Allergic Rhinitis: A Comparative Study

The study found that both C+P and L+P effectively reduced nasal symptoms in patients with perennial allergic rhinitis. While both combinations provided significant symptom relief, C+P demonstrated slightly better outcomes for sneezing and nasal congestion. The study suggests that C+P may offer a slight edge in managing specific symptoms, although the overall difference between the two groups was not statistically significant.

Managing Allergic Rhinitis: A Desert of Sneezes

Navigating the challenges of allergic rhinitis can feel like a desert journey, with frequent sneezing and nasal congestion as unwelcome companions. This study offers valuable insights into the comparative efficacy of two common treatment options, highlighting the potential for C+P to provide slightly better relief for certain symptoms. It is crucial to consult with a healthcare professional to determine the most appropriate treatment for individual needs.

Dr.Camel's Conclusion

This study is a reminder that even in the vast desert of allergic rhinitis, there can be subtle variations in the effectiveness of different treatment approaches. The study's findings suggest that C+P may offer a slight advantage for managing specific symptoms, but further research is needed to confirm this finding.
Date :
  1. Date Completed 2007-01-18
  2. Date Revised 2016-10-21
Further Info :

Pubmed ID

17136873

DOI: Digital Object Identifier

17136873

Related Literature

Article Analysis
・Side Effects of pseudoephedrine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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