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Effects of a 7-day treatment with midodrine in non-azotemic cirrhotic patients with and without ascites.

Author: EconomouMichalis, FotopoulosAndreas, KalambokisGeorgios, PappasKonstantinos, TsianosEpameinondas V

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Midodrine, an alpha1-adrenergic agonist, was evaluated for its effects on splanchnic arterial vasodilatation in cirrhotic patients with and without ascites. After 7 days of treatment, midodrine improved splanchnic vasoconstriction in patients with ascites and also improved sodium excretion.
Paper Details　
Original Abstract of the Article :
Splanchnic arterial vasodilatation has been causally related with hyperdynamic circulation and impaired natriuresis in advanced cirrhosis and has also been suggested to be responsible for the subtle sodium retention in pre-ascitic cirrhosis. This study evaluated the effects of a 7-day treatment with...See full text at original site
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引用元：
https://doi.org/10.1016/j.jhep.2006.09.012

データ提供：米国国立医学図書館（NLM）

Midodrine: A Potential Treatment for Cirrhosis-Related Symptoms

Cirrhosis, a serious liver disease, can lead to a range of symptoms, including fluid buildup in the abdomen (ascites) and hyperdynamic circulation. This study investigates the effects of a 7-day treatment with midodrine, an alpha1-adrenergic agonist, in non-azotemic cirrhotic patients with and without ascites. The study explores the potential of midodrine to improve blood pressure and reduce fluid retention.

Midodrine: A Potential Oasis in the Desert of Cirrhosis

The study provides evidence that midodrine could be a potential therapeutic option for managing the symptoms of cirrhosis. This is a promising development for patients with cirrhosis, as it could offer relief from the debilitating symptoms of the disease.

Navigating the Shifting Sands of Cirrhosis

Cirrhosis is like navigating a desert landscape, with ever-shifting sands and unpredictable challenges. Midodrine offers a potential path to stability, potentially improving blood pressure and reducing fluid buildup. However, it’s important to remember that cirrhosis is a complex disease, and treatment should be tailored to individual needs.

Dr.Camel's Conclusion

This study provides a promising glimpse into the potential of midodrine in managing cirrhosis-related symptoms. Further research is needed to confirm its long-term efficacy and safety, but it offers a glimmer of hope for patients dealing with this challenging condition.

Date :
  1. Date Completed 2007-03-16
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17156883

DOI: Digital Object Identifier

10.1016/j.jhep.2006.09.012

Related Literature

Article Analysis
・Effects of midodrine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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