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Pro-oxidant effects of Mebendazole in albino rats experimentally infected with Trichinella spiralis.

Author: LangrovaI, LytvynetsA, TolstojV A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mebendazole, an anthelmintic drug, amplifies lipid peroxidation processes in the blood of both infected and parasite-free animals.
Paper Details　
Original Abstract of the Article :
Trichinellosis treated with Mebendazole often leads to complications in the course of the disease in humans and animals as a result of intoxication and hyper-sensitization of an organism due to the massive destruction of parasites. This study was conducted to research Mebendazole incidence on lipid ...See full text at original site
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引用元：
https://doi.org/10.1007/s00436-006-0401-y

データ提供：米国国立医学図書館（NLM）

Investigating the Pro-Oxidant Effects of Mebendazole

Trichinellosis, a parasitic infection caused by the roundworm Trichinella spiralis, can be a challenging condition to treat. This research explores the potential pro-oxidant effects of mebendazole, a commonly used antiparasitic medication, in rats infected with Trichinella spiralis. This research highlights the importance of understanding the potential side effects of mebendazole and the need for careful monitoring during treatment.

Exploring the Potential Side Effects of Mebendazole

The study examined the effects of mebendazole on lipid peroxidation processes (LPP) in the blood of rats infected with Trichinella spiralis. The study found that mebendazole amplified LPP, suggesting that the drug may have pro-oxidant effects. This research underscores the importance of considering the potential side effects of mebendazole, particularly in cases of high-dose administration.

Understanding the Risks and Benefits of Mebendazole

This research provides valuable insights into the potential pro-oxidant effects of mebendazole, highlighting the need for careful monitoring during treatment. The findings suggest that mebendazole, while effective in treating trichinellosis, may also have potential adverse effects on oxidative stress. This research encourages further investigation to optimize the use of mebendazole, maximizing its efficacy while minimizing potential risks.

Dr. Camel's Conclusion

This study highlights the complexities of managing parasitic infections and the importance of understanding the potential side effects of medications. The research underscores the need for a careful assessment of risks and benefits when considering mebendazole treatment. As a desert-dwelling explorer, I am always mindful of the delicate balance between the potential benefits and risks of any intervention. This research is a reminder that even seemingly benign treatments can have unexpected consequences.

Date :
  1. Date Completed 2007-08-14
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

17186274

DOI: Digital Object Identifier

10.1007/s00436-006-0401-y

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in preparation
Languages

English

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