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The effects of thyroid hormone on insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) expression in the neonatal rat: prolonged high expression of IGFBP-2 in methimazole-induced congenital hypothyroidism.

Author: GlasscockG F, Näntö-SalonenK, RosenfeldR G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Thyroid hormone is essential for some of the neonatal changes in IGF and IGFBP profiles in rats. In a study of hypothyroid rats, the animals lacked the steep rise in serum IGF-I levels normally occurring during the third week of life.
Paper Details　
Original Abstract of the Article :
In the rat a developmental switch in the serum insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) profile takes place during the first 3 postnatal weeks. The fetal expression pattern of high IGF-II and IGFBP-2 is replaced by the adult pattern of low levels of IGF-II and IGFBP-2 and hig...See full text at original site
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引用元：
https://doi.org/10.1210/endo-129-5-2563

データ提供：米国国立医学図書館（NLM）

Thyroid Hormone: A Vital Conductor in the Symphony of Growth

The intricate dance of growth and development is a symphony orchestrated by a complex interplay of hormones. This research focuses on the role of thyroid hormone, a vital conductor in this symphony, particularly its influence on insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) expression in neonatal rats. The study investigates the impact of hypothyroidism, akin to a disruption in the orchestra's rhythm, on the delicate balance of growth factors, shedding light on the crucial role of thyroid hormone in early development.

Unraveling the Impact of Hypothyroidism

Using a rat model of congenital hypothyroidism, the researchers observed a significant delay in growth and a disruption in the normal IGF and IGFBP profile. The hypothyroid pups exhibited a marked reduction in IGF-I levels, a key player in promoting growth, a testament to the crucial role of thyroid hormone in regulating this important growth factor. Additionally, the hypothyroid rats continued to express high levels of IGFBP-2, a protein that binds to IGF, potentially hindering its growth-promoting effects. These findings highlight the profound impact of thyroid hormone on the delicate dance of growth factors during early development.

A Symphony of Growth and Development

The study underscores the importance of ensuring adequate thyroid function during early development, akin to providing the necessary instruments and tuning for a harmonious orchestra. This research provides valuable insights into the complex interactions within the body, reminding us that every hormone plays a crucial role in the symphony of life.

Dr. Camel's Conclusion

This study reveals the crucial role of thyroid hormone in orchestrating the symphony of growth and development. It's a reminder that even seemingly subtle disruptions in this delicate balance can have profound consequences. By understanding these intricate interactions, we can ensure that the orchestra of life plays in harmony, leading to healthy growth and development.
Date :
  1. Date Completed 1991-12-02
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1718729

DOI: Digital Object Identifier

10.1210/endo-129-5-2563

Related Literature

Article Analysis
・Effects of methimazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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